The aerobic oxidation of pyrrolones catalyzed by Fe(OTf)3 to form reactive N-acyliminium ion intermediates that undergo nucleophilic additions with alcohols to give the corresponding products in moderate to good yields is described.
Small-ring silacycles are important
organosilane species in main-group
chemistry and have found numerous applications in organic synthesis.
3-Silaazetidine, a unique small silacycle bearing silicon and nitrogen
atoms, has not been adequately explored due to the lack of a general
synthetic scheme and its sensitivity to air. Here, we describe that
3-silaazetidine can be easily prepared in situ from
diverse air-stable precursors (RSO2NHCH2SiR1
2CH2Cl). 3-Silaazetidine shows excellent
functional group tolerance in a palladium-catalyzed ring expansion
reaction with terminal alkynes, giving 3-silatetrahydropyridines and
diverse silaazacycle derivatives, which are promising ring frameworks
for the discovery of Si-containing functional molecules.
In this study, a concise and atom-economical TfOH-mediated [2 + 2 + 2] cycloaddition of ynamides with two discrete nitriles is developed to synthesize multi-substituted 4-aminopyrimidine.
A metal-free regio- and stereoselective method is achieved for the preparation of ( E)-configured α-halo enamides, vinyl thioethers, and vinyl ethers using aqueous HX (X = F, Cl, Br, I), which features high functional group compatibility and regio- and stereoselectivity, mild conditions, high efficiency, and rapid transformation. Additionally, the isomers could be yielded readily from the ( E)-configured α-halo enamides via photocatalysis or under Sonogashira coupling conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.