Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of <scp><i>Curcuma longa</i></scp> and curcumin, an updated and comprehensive review

Memarzia, Arghavan; Khazdair, Mohammad Reza; Behrouz, Sepideh; Gholamnezhad, Zahra; Jafarnezhad, Maryam; Saadat, Saeideh; Boskabady, Mohammad Hossein

doi:10.1002/biof.1716

Cited by 94 publications

(62 citation statements)

References 244 publications

(254 reference statements)

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“…They found that curcumin increased the expression and production of IL-10 in many different tissues, taking results from 36 studies. In parallel, pro-inflammatory cytokines (IL-1β, IL-4, IL-6, IL-10, IL-12, IL-18, TNF-α) and chemokines (macrophage inflammatory protein-1 alpha and monocyte chemoattractant protein-1) were found to be decreased by curcumin, as discussed in the literature (Ghosh, Banerjee, and Sil, 2015;Memarzia et al, 2021). Interestingly, Memarzia et al ( 2021) highlighted curcumin's role at both increasing and decreasing IL-10 levels.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 63%

“…Of these, NF-κB has been most discussed. In this connection, interleukins were found to decrease through NF-κB (He et al, 2015) which was in turn inhibited through inhibition of toll-like receptor-4 and MyD88 (Memarzia et al, 2021). Furthermore, as an NF-κB suppressor, curcumin was found to prevent inflammationinduced apoptosis of chondrocytes in osteoarthritis (Chin, 2016).…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 95%

“…Curcumin functions through several anti-inflammatory pathways. These include the Keap1-Nrf2, AKT and ERK, MAPK, STAT, AP-1, and NF-κB pathways (He et al, 2015;Memarzia et al, 2021). Of these, NF-κB has been most discussed.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

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Spices and herbs as immune enhancers and anti-inflammatory agents: A review

Garnier¹,

Shahidi²

2021

JFB

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Spices and herbs have been used in traditional medicine for centuries, with research starting to accumulate on their beneficial properties. Of these properties, the immune-enhancing and anti-inflammatory capabilities of many spices and herbs have led to promising results. The current review article aims to explore the current research of several spices and herbs as immune-enhancers and anti-inflammatory agents. The spices and herbs examined are African potato (Hypoxis hemerocallidea), allspice (Pimenta dioica), basil (Ocimum basilicum), black pepper (Piper nigrum), chili powders (Capsicum species), clove (Syzygium aromaticum), Devil’s claw (Harpagophytem procumbens), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), lavender (Lavandula angustifolia), oregano (Origanum vulgare), rooibos (Aspalathus linearis), rosemary/sage (Salvia rosmarinus/officinalis), saffron (Crocus sativus), South African geranium (Pelargonium sidoides), and turmeric (Curcuma longa). All the spices and herbs exhibited immune-enhancing or immunomodulatory and anti-inflammatory capabilities through various processes. Rooibos and oregano had the most contradictory results, with some studies finding pro-inflammatory properties, especially at high doses regarding oregano. Turmeric had the most extensive research with positive results.

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Section: Anti-inflammatory Propertiesmentioning

confidence: 63%

Section: Anti-inflammatory Propertiesmentioning

confidence: 95%

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Spices and herbs as immune enhancers and anti-inflammatory agents: A review

Garnier¹,

Shahidi²

2021

JFB

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“…The spice turmeric has been used in traditional Asian medicine for thousands of years [34]. The active component, known as curcumin, can be isolated from the C. longa plant by drying and powdering of the roots [35]. Administration of curcumin as a nutritional supplement is complicated due to its hydrophobic nature resulting in low bioavailability.…”

Section: Curcuminmentioning

confidence: 99%

Molecular Aspects in the Potential of Vitamins and Supplements for Treating Diabetic Neuropathy

Okdahl

Brock

2021

Curr Diab Rep

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Purpose of Review To discuss and provide evidence-based data on dietary supplements as part of treating diabetic neuropathy Recent Findings Few randomized controlled trials are available, but some have shown beneficial efficacy of various dietary supplements on objective primary endpoints including nerve conduction velocities and axon potentials as well as subjective patient-reported outcomes. Summary No medical cure for diabetic neuropathy exists, and prevention is therefore crucial. Tight glucose control slows the progression of nerve damage in diabetes, but an unmet clinical need for effective interventions is warranted. Consequently, a growing number of patients turn to dietary supplements proposed to possess neuroprotective properties. However, the postulated effects are often not evidence-based as they have not been tested scientifically. Taken together, this review will focus on dietary supplements investigated in clinical trials for their potential capabilities in targeting the molecular mechanisms involved in the underlying pathogenesis of diabetic neuropathy.

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“…Nonetheless, curcumin, DMC, and BMC have been isolated from various Curcuma spp., including (6)(7)(8)(9). Several pharmacological activities have been ascribed to curcumin as a pure compound, such as antioxidant, antimicrobial and anti-inflammatory properties (10)(11)(12). The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in inflammation and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review

Cited by 94 publications

References 244 publications

Spices and herbs as immune enhancers and anti-inflammatory agents: A review

Spices and herbs as immune enhancers and anti-inflammatory agents: A review

Molecular Aspects in the Potential of Vitamins and Supplements for Treating Diabetic Neuropathy

The pharmacological basis of the curcumin nutraceutical uses: an update

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