The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro, Donatella; Chiavaroli, Annalisa; Cicia, Donatella; Cimino, Francesco; Currò, Diego; Dell’Agli, Mario; Ferrante, Claudio; Giovannelli, Lisa; Leone, Sheila; Martinelli, G.; Milella, Luigi; Pagano, Ester; Piazza, Stefano; Ponticelli, Maria; Recinella, Lucia; Ristori, S.; Sangiovanni, Enrico; Smeriglio, Antonella; Speciale, Antonio; Trombetta, Domenico; Vivarelli, Fabio

doi:10.36118/pharmadvances.2021.06

Cited by 19 publications

(19 citation statements)

References 276 publications

(344 reference statements)

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“…3-5%), and THC being the major metabolite of curcumin [7]. We measured the plasma levels of CUR, DMC, BDMC, and THC which are known to be responsible for the diverse bioactivity of curcuminoids [8,[24][25][26][27] and represented the data for total curcuminoids. Our study results showed that the plasma concentrations of total curcuminoids and its bioavailability were significantly higher for both doses (250 and 500 mg) of CU?…”

Section: Discussionmentioning

confidence: 99%

Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Kothaplly¹,

Alukapally²,

Nagula³

et al. 2022

Adv Ther

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Background: Despite its broad range of biological activities, use of curcumin is limited because of poor bioavailability. Here we report a novel curcumin formulation, Curcuwin Ultra? (CU?), with superior bioavailability as compared to 95% turmeric extract (TUR 1800). Methods: A randomized, double-blind, threetreatment, crossover oral bioavailability study was conducted in 24 healthy volunteers under fasting conditions. Subjects received a single dose of CU? 250 mg, 500 mg and 1900 mg of TUR1800 as per randomization schedule and blood samples were collected at 4 h and 0 h before dosing, and 0.5,

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Section: Discussionmentioning

confidence: 99%

Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Kothaplly¹,

Alukapally²,

Nagula³

et al. 2022

Adv Ther

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“…The curcumin concentration is critical for evaluating the biological consequences of frequent oral intake. Bio-transformed moieties, such as tetra hexahydro–curcumin, have drawn attention because of their poor systemic bioavailability [ 87 ].…”

Section: Phytomedicine Drug Delivery Using Nanoparticlesmentioning

confidence: 99%

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

et al. 2022

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Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the world, despite considerable advances in therapy. The formation of colorectal adenomas and invasive adenocarcinomas is the consequence of a succession of genetic and epigenetic changes in the normal colonic epithelium. Genetic and epigenetic processes associated with the onset, development, and metastasis of sporadic CRC have been studied in depth, resulting in identifying biomarkers that might be used to predict behaviour and prognosis beyond staging and influence therapeutic options. A novel biomarker, or a group of biomarkers, must be discovered in order to build an accurate and clinically useful test that may be used as an alternative to conventional methods for the early detection of CRC and to identify prospective new therapeutic intervention targets. To minimise the mortality burden of colorectal cancer, new screening methods with higher accuracy and nano-based diagnostic precision are needed. Cytotoxic medication has negative side effects and is restricted by medication resistance. One of the most promising cancer treatment techniques is the use of nano-based carrier system as a medication delivery mechanism. To deliver cytotoxic medicines, targeted nanoparticles might take advantage of differently expressed molecules on the surface of cancer cells. The use of different compounds as ligands on the surface of nanoparticles to interact with cancer cells, enabling the efficient delivery of antitumor medicines. Formulations based on nanoparticles might aid in early cancer diagnosis and help to overcome the limitations of traditional treatments, including low water solubility, nonspecific biodistribution, and restricted bioavailability. This article addresses about the molecular pathogenesis of CRC and highlights about biomarkers. It also provides conceptual knowledge of nanotechnology-based diagnostic techniques and therapeutic approaches for malignant colorectal cancer.

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“…Curcumin is a well-known curcuminoid extracted from the rhizome of Curcuma longa . Various biological activities of curcumin have been described in the literature including antioxidant, antimicrobial, and anti-inflammatory properties [ 12 ]. Zoi V. et al [ 13 ] explored the possible use of curcumin as a radio-sensitizing agent in the treatment of glioblastoma, the most common and severe malignant brain tumor.…”

Section: Recent Advances In the Role Of Polyphenols In Inflammatory Conditionsmentioning

confidence: 99%

Special Issue: Anti-Inflammatory Activity of Plant Polyphenols 2.0

Sangiovanni

Dell’Agli

2021

Biomedicines

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The pharmacological basis of the curcumin nutraceutical uses: an update

Cited by 19 publications

References 276 publications

Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Special Issue: Anti-Inflammatory Activity of Plant Polyphenols 2.0

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