Experimental analysis of a chiral separation through simulated moving bed chromatography

Simulated moving-bed adsorption for separation of racemic mixtures

“…Porosity of the bed of MCTA packed in the columns was measured following the protocol described by Pedeferri et al (1999). Each of the eight columns necessary for operation of the SMB unit, containing the MCTA packed bed, was individually coupled to the HPLC system, and 1,3,5 -Tri-tert-butylbenzene was injected into each one of them.…”

“…Then the retention time of each enantiomer is measured, which allows determination of the linear isotherms, valid for dilute systems. The isotherms are represented by the Henry constants, given by (Pedeferri et al, 1999) …”

Shortcut experimental method for designing chiral SMB separations

“…Moreover, under linear conditions the scale-up of the separation from the HPLC to the SMB is rather straightfor-Ž . ward Yun et al, 1997c;Pedeferri et al, 1999 . This allows the time to develop a new product to be significantly shortened.…”

“…et al, 1997 , and an increased separation performance, which allows product recovery at high purities even when the selecCorrespondence concerning this article should be addressed to M. Morbidelli. tivity is close to one or the efficiency of the stationary phase Ž . is low Yun et al, 1997c;Pedeferri et al, 1999 . Although these properties are attractive, the key to the success of this unit operation rests on its flexibility and fast Ž scale-up. The same SMB unit equipped with the same or .…”

“…Pais et al, 1997;Wu et al, 1998;Migliorini et al, 1999a or Ž . ideal models Francotte et al, 1998;Pedeferri et al, 1999 is possible, but it requires knowledge of the adsorption equilibria. The determination of such equilibria is time-consuming, and in addition it depends on the availability of large amounts of pure substances, and therefore it may not be feasible in the early development of a new product, particularly in the pharmaceutical industry.…”