Experimental alcoholism primes structural and functional impairment of the glymphatic pathway

Liu, Qiang; Yan, Lilong; Huang, Miaodan; Zeng, Haitao; Satyanarayanan, Senthil Kumaran; Shi, Zhe; Chen, Dingbang; Lu, Jiahong; Pei, Zhong; Yao, Xiaoli; Su, Huanxing

doi:10.1016/j.bbi.2019.06.029

Cited by 17 publications

(13 citation statements)

References 66 publications

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“…In recent years, a large number of studies have tried to use visualization technology to observe and describe the glymphatic system. The initial study used two-photon imaging observations, including fluorescent tracers and laser scanning microscopes, to discover the relationship between the glymphatic system and sleep ( Xie et al, 2013 ) and found that alcoholism may lead to glymphatic system dysfunction ( Liu Q. et al, 2020 ). Although optical imaging technology, such as two-photon microscopy, occupies a dominant position in the classical field, it is gradually being replaced by MRI because of its strong invasiveness.…”

Section: Imaging Studymentioning

confidence: 99%

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Zhang

2022

Front. Aging Neurosci.

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The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techniques for the glymphatic system currently available. The perfection of the glymphatic system hypothesis and the exploration of the effects of aging and endocrine factors on the central and peripheral regulatory pathways through the glymphatic system still require exploration in the future.

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Section: Imaging Studymentioning

confidence: 99%

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Zhang

2022

Front. Aging Neurosci.

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“…Alcoholism is also reportedly linked to glymphatic dysfunction. A two‐photon laser scanning microscopy study with fluorescent tracer showed that acute moderate alcohol administration substantially retarded and reduced the entry of CSF into the cerebral parenchyma, thus impairing amyloid β clearance . Similarly, in psychiatric disorders, involvement of abnormal CSF dynamics or glymphatic function have been suggested.…”

Section: Clinical Implications and Future Perspectives On The Glymphamentioning

confidence: 99%

Glymphatic imaging using MRI

Taoka

Naganawa

2019

Magnetic Resonance Imaging

110

152

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FIGURE 6: Dynamic curves of relative signals after injection of 17O-labeled water. Dynamic curves of relative signal intensity. A bolus injection of saline or 17O was initiated 120 seconds after starting a scan. Significant drops in signal were observed in the cerebral cortex (a), choroid plexus (d), ventricle (e), and subarachnoid space (f) in the 17O condition, while only slight reductions in signal were noted in the basal ganglia/thalamus (b) and white matter (c). In the cerebral cortex, choroid plexus, and subarachnoid space, the curves are characterized by two phases: an initial signal drop and a plateau phase. In the ventricle, the signals gradually and continuously decreased during the acquisition window.

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“…The study of the problem of alcoholism is relevant. [1][2][3][4] Alcoholism affects the central nervous system, 5,6 cardiovascular, 7,8 and digestive systems. 9,10 Female alcoholism is especially dangerous, as its consequence is the birth of children with fetal alcohol syndrome (FAD).…”

Section: Introductionmentioning

confidence: 99%

Development of the Heart Muscle after Antenatal Ethanol Intoxication during the Neonatal Period

Zhanaidarova¹,

Наурызов

Nurseitova

et al. 2022

Bangladesh J Med Sci

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Objective: The aim of the study was to study the effect of antenatal ethanol intoxication on the postnatal development of the heart muscle during the neonatal period. Materials and methods: The experiment was carried out on 24 pregnant female rats weighing 180-200 grams. The animals were divided into 2 groups: experimental and control. 12 animals of the experimental group were injected with a 30% ethanol solution from 6 to 21 days of gestation daily, once, endogastrically, at a dose of 5 g / kg. The animals of the control group were injected with the same volume of physiological saline. Results and Discussion: On the 1st and 7th days after birth, the rat pups were killed by decapitation under light ether anesthesia. After determining the mass of the heart, part of the organ was studied electron microscopically, part was fixed in 10% neutral formalin, then histological preparations were prepared in accordance with standard methods. Sections were stained with hematoxylin and eosin. The nuclear-cytoplasmic ratio in cardiomyocytes, the specific density of the capillary network of the myocardium, and the specific density of cardiomyocytes were measured. The data obtained were statistically processed. Conclusion: The study showed that antenatal ethanol intoxication has a pronounced effect on the postnatal development of the heart muscle during the neonatal period, which manifests itself at the cellular and subcellular levels. The value of the obtained results lies in the fact that for the first time ultrastructural changes in postnatal development in the neonatal period of the fetal heart muscle during prenatal ethanol intoxication are shown at the electron microscopic level. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 344-353

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Experimental alcoholism primes structural and functional impairment of the glymphatic pathway

Cited by 17 publications

References 66 publications

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Glymphatic imaging using MRI

Development of the Heart Muscle after Antenatal Ethanol Intoxication during the Neonatal Period

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