Experimental Acute Necrotising Pancreatitis: Evaluation and Characterisation of a Model of Intraparenchymal Injection of Sodium Taurocholate in Rats

Paran, Haim; Mayo, Ami; Kidron, Dvora; Sivak, Galit; Reshef, Tamar; Vider, Tsahi; Ziv, Ofer; Freund, U

doi:10.1080/110241500447308

Cited by 10 publications

(3 citation statements)

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“…Moreover, targeted treatments should be tested carefully before going to a clinical trial to ensure that there are no harmful adverse effects. 2,3 Cytokine production represents a relevant aspect of inflammatory response that in the last decade has catalyzed basic and clinical research on AP. Tumor necrosis factor > (TNF->) is a macrophage, lymphocyte-derived cytokine with a broad spectrum of immunoregulatory, metabolic, and proinflammatory activities.…”

mentioning

confidence: 99%

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Yılmaz¹,

Tekekoglu²,

Herek³

et al. 2010

Pancreas

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mentioning

confidence: 99%

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Yılmaz¹,

Tekekoglu²,

Herek³

et al. 2010

Pancreas

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“…Pancreatic and biliary duct retrograde infusions of 3.0% sodium taurocholate (0.1 mL/100 g), as described by Paran et al [26], were used to induce a model of SAP with SIRS. Rats in the sham-operation group only had their abdomen opened and closed.…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca²⁺-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis

Wang

Teng

et al. 2016

BioMed Research International

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Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism underlying the effect of emodin remains unclear. This study was designed to explore the protective effects and underlying mechanisms of emodin against SIRS in rats with SAP. In the present study, cytosolic Ca2+ levels, calpain 1 activity, and the expression levels of the active fragments of caspases 12 and 3 decreased in neutrophils from rats with SAP and increased after treatment with emodin. Delayed neutrophil apoptosis occurred in rats with SAP and emodin was able to reverse this delayed apoptosis and inhibit SIRS. The effect of emodin on calpain 1 activity, the expression levels of the active fragments of caspases 12 and 3, neutrophil apoptosis, and SIRS scores were attenuated by PD150606 (an inhibitor of calpain). These results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca2+-calpain 1-caspase 12-caspase 3 signaling pathway.

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“…Paran et al showed that six hours after injection plasma activites of amylase, lipase and lactate dehydrogenase increase and twenty four hours after injection pancreatic morphological changes with good correlation to clinical findings and mortality were seen [99].…”

Section: Intraparenchymal Taurocholate Injectionmentioning

confidence: 99%

Basic Experimental Pancreatitis Models for Beginners

Yildiz¹,

Hamaloğlu²

2010

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Efforts to find an ideal model for pancreatitis date back to 1960's. Many models are suggested since then. Every model has its own advantages and disadvantages. Some of these models test etiology while others simulate the complications of pancreatitis. An ideal model which by itself demonstrates all aspects of pancreatitis including systemic changes is yet to be described. In this review we tried to gather the basic, easy to construct models.

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Experimental Acute Necrotising Pancreatitis: Evaluation and Characterisation of a Model of Intraparenchymal Injection of Sodium Taurocholate in Rats

Abstract: The intraparenchymal injection of taurocholate is easy to perform and highly reproducible. The histopathological injury is dose-dependent, as is the mortality. We conclude that this model is valuable for the study of new treatments for pancreatitis.

Cited by 10 publications

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Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca²⁺-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis

Basic Experimental Pancreatitis Models for Beginners

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Experimental Acute Necrotising Pancreatitis: Evaluation and Characterisation of a Model of Intraparenchymal Injection of Sodium Taurocholate in Rats

Abstract: The intraparenchymal injection of taurocholate is easy to perform and highly reproducible. The histopathological injury is dose-dependent, as is the mortality. We conclude that this model is valuable for the study of new treatments for pancreatitis.

Cited by 10 publications

References 0 publications

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca2+-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis

Basic Experimental Pancreatitis Models for Beginners

Contact Info

Product

Resources

About

Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca²⁺-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis