This paper reports our investigation of wireless communication performance obtained using orbital angular momentum (OAM) multiplexing, from theoretical evaluation to experimental study. First, we show how we performed a basic theoretical study on wireless OAM multiplexing performance regarding modulation, demodulation, multiplexing, and demultiplexing. This provided a clear picture of the effects of mode attenuation and gave us insight into the potential and limitations of OAM wireless communications. Then, we expanded our study to experimental evaluation of a dielectric lens and end-to-end wireless transmission on 28 gigahertz frequency bands. To overcome the beam divergence of OAM multiplexing, we propose a combination of multi-input multi-output (MIMO) and OAM technology, named OAM-MIMO multiplexing. We achieved 45 Gbps (gigabits per second) throughput using OAM multiplexing with five OAM modes. We also experimentally demonstrated the effectiveness of the proposed OAM-MIMO multiplexing using a total of 11 OAM modes. Experimental OAM-MIMO multiplexing results reached a new milestone for point-to-point transmission rates when 100 Gbps was achieved at a 10-m transmission distance.