Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea

Rusnak, Janice M.; Byrne, William R.; Chung, Kyung N.; Gibbs, Paul; Kim, Theodore T.; Boudreau, Ellen F.; Cosgriff, Thomas M.; Pittman, Phillip R.; Kim, Katie Y.; Erlichman, Marianne S.; Rezvani, David F.; Huggins, John W.

doi:10.1016/j.antiviral.2008.09.007

Cited by 82 publications

(63 citation statements)

References 33 publications

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“…88 A clinical study using intravenous ribavirin for treating Department of Defense personnel with HFRS acquired in Korea from 1987 to 2005 demonstrated a low rate of oliguria (3%) and the absence of dialysis requirement in the treatment cohort (33 individuals); these findings support previous reports that ribavirin given early results in decreased severity of renal insufficiency. 89 On the other hand, the results of trials in patients suffering from HCPS yielded disappointing results. 90,91 Recently, 1-beta-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR) was identified to be promising antiviral candidate with activity against HTNV and ANDV.…”

Section: Chemoprophylaxismentioning

confidence: 99%

Human pathogenic hantaviruses and prevention of infection

2011

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Section: Chemoprophylaxismentioning

confidence: 99%

Human pathogenic hantaviruses and prevention of infection

2011

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“…Estudos realizados na China com pacientes com FHSR sugerem que a aplicação de ribavirina endovenosa, por 7 dias, produz uma melhora no prognóstico quando utilizada precocemente no curso da doença, diminuindo a morbidade e mortalidade 24 .…”

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Síndrome pulmonar e cardiovascular por hantavírus: aspectos clínicos de uma doença emergente no sudeste brasileiro

Borges

Badra

Figueiredo

et al. 2009

Rev. Soc. Bras. Med. Trop.

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ARTIGO/ARTICLEAs doenças emergentes que são, em grande parte, frutos de alterações no ecossistema e dos comportamentos econômicos, sociais e culturais do homem, preocupam as autoridades sanitárias em todo o mundo. Estas doenças surgem como importante problema de saúde pública, tanto nas zonas rurais como nas urbanas. Dentre aquelas que despertam especial preocupação estão as febres hemorrágicas, como é o caso da síndrome pulmonar e cardiovascular por hantavírus (SPCVH), ABSTRACTPulmonary and cardiovascular syndrome due to hantavirus is a disease caused by inhalation of aerosols from the excreta of wild rodents contaminated by viruses of the Bunyaviridae family. We studied the clinical and laboratory manifestations of 70 cases that occurred in the region of Ribeirão Preto, SP, Brazil, between 1998 and 2007. The frequency of symptoms was as follows: dyspnea (87%), fever (81%), coughing (44%), headache (34%), tachycardia (81%), low arterial blood pressure (56%), metabolic acidosis (57%), lymphocytopenia (51%), hematocrit > 45% (70%), leukocytosis with left deviation (67%), creatinine (51%) and urea (42%). Mortality (54.3%) occurred mainly on the fourth day. Respiratory insufficiency, low arterial blood pressure and shock occurred after 24 to 48 hours. High hematocrit and decreased platelet levels were signs strongly suggestive of the disease. The diagnostic hypothesis of atypical pneumonia was associated with a good prognosis (p = 0.0136). Fluid infusion greater than 2,000 ml and arterial hypotension were associated with a poor prognosis (p = 0.0286 and p = 0.0453).

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“…Bu çalışmada hastalığın ilk 7 günü içerisinde başlanan İV ribavirin tedavisinin mortaliteyi yedi kat azalttığı saptanmıştır (27). Yakın zamanda Kore'de yapılan bir kohort çalışmasında 1987-2005 arasında İV ribavirin alan 33 RSKA olgusu, ribavirin tedavisi almayan tarihsel kontrollerle kıyaslanmıştır (28). Tarihsel veriler Kore'de RSKA olgularının %39-69'unda oligüri geliştiğini ve yaklaşık %40'ında diyaliz gereksinimi ortaya çıktığını göster-mektedir.…”

Section: Tedaviunclassified

“…Oysa İV ribavirin alan 33 hastanın yalnızca %3'ünde oligüri gelişmiştir ve hiçbirinde diyaliz gereksinimi ortaya çık-mamıştır. Rusnak ve arkadaşları (28), bu verilere dayanarak İV ribavirin tedavisinin RSKA olgularında oligüri gelişimini ve böbrek yetmezliğinin şiddetini azalttığını bildirmiştir.…”

Section: Tedaviunclassified

Hantavirus Infections

Çelebi¹

2012

Klimik Dergisi

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ÖzetHantaviruslar, Bunyaviridae ailesinin Hantavirus cinsinde yer alan, kemirici (rodent) veya böcekçil (insektivor) kaynaklı, zarflı bir RNA virusu grubudur. Her hantavirus tipi o tipe özgü bir kemirici türü tarafından taşınır. Günümüze kadar 45 civarında hantavirus tipi saptanmış ve en az 20 tanesi insanlarda infeksiyon etkeni olarak gösterilmiştir. Hantaviruslar kemiricilerde çoğunlukla asemptomatik fakat kronik bir infeksiyona neden olur. Kemiriciler idrar ve dışkılarıyla aylarca çevreye virus saçar-lar. Amerika kıtasında bulunan hantavirus tipleri (Sin Nombre virusu, Andes virusu, Laguna Negra virusu, New York virusu vb.) hantavirus pulmoner sendromuna (HPS) neden olur ve oluşan infeksiyonun fatalitesi oldukça yüksektir (%30 civarında AbstractHantaviruses belonging to the Bunyaviridae family, and the genus Hantavirus, are a group of rodent-or insectivore-borne RNA viruses. Each Hantavirus type is carried by a specific rodent host species. Up to now, approximately 45 hantavirus types have been isolated and at least 20 have been identified as infectious agents in humans. Hantaviruses mostly cause asymptomatic but chronic infections in rodents. Rodents spread the viruses on the surfaces in the environment with their urine and feces during several months. Hantavirus types which exist in the Americas (Sin Nombre virus, Andes virus, Laguna Negra virus, New York virus etc.) cause Hantavirus pulmonary syndrome (HPS) and the fatality rate of the disease is quite high (around 30%). Hantavirus types which exist in Europe and Asia (Hantaan virus [HTNV], Seoul virus [SEOV], Dobrova virus [DOBV], Puumala virus [PUUV]) cause hemorrhagic fever with renal syndrome (HFRS). HTNV and SEOV in Asia, and PUUV and DOBV in Europe are the major agents of HFRS. Infection caused by HTNV or DOBV is a more serious disease with a fatality rate around 5-10%, while infection caused by PUUV is a mild disease with a fatality rate around 0.1%. Ribavirin was found to be effective in the treatment of HFRS in a few studies conducted in China and Korea. However, it was found to be ineffective in the treatment of HPS in America. The most effective method for prevention seems to be vaccination and studies are still ongoing for a safe and effective vaccine. The first human hantavirus outbreak in Turkey confirmed clinically and serologically was detected in the Zonguldak-Bartın region in February 2009. PUUV and DOBV were isolated from tissue samples of rodents captured in the outbreak region by using polymerase chain reaction and viral cell culture. Considering the current rodent and insectivore species in the country, in addition to PUUV and DOBV, the presence of Saaremaa virus, SEOV, Tula virus and Seewis virus may be anticipated in Turkey. Klimik Dergisi 2011; 24(3): 139-49.

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Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea

Cited by 82 publications

References 33 publications

Human pathogenic hantaviruses and prevention of infection

Human pathogenic hantaviruses and prevention of infection

Síndrome pulmonar e cardiovascular por hantavírus: aspectos clínicos de uma doença emergente no sudeste brasileiro

Hantavirus Infections

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