Experience with Clinically Diagnosed Down Syndrome Children Admitted with Diarrhea in an Urban Hospital in Bangladesh

Abstract

There is lack of information in the medical literature on clinically diagnosed Down syndrome children presenting with diarrhea. Our aim was to describe our experience with Down syndrome patients admitted with diarrhea by evaluating the factors associated with Down syndrome presenting with diarrheal illness. In this retrospective chart analysis, we enrolled all the diarrheal children aged 0–59 months admitted to the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (icddr, b), from March 2011 to February 2013. Down syndrome children with diarrhea constituted cases and randomly selected threefold diarrheal children without Down syndrome constituted controls. Among 8422 enrolled children 32 and 96 were the cases and the controls, respectively. Median age (months) of the cases and the controls was comparable (7.6 (4.0, 15.0) versus 9.0 (5.0, 16.8); p = 0.496). The cases more often presented with severe acute malnutrition, developmental delay, congenital heart disease, hypothyroidism, sepsis, hypocalcemia, developed hospital acquired infection (HAI) during hospitalization, and required prolonged stay at hospital compared to the controls (for all p < 0.05). Thus, diarrheal children with clinically diagnosed Down syndrome should be investigated for these simple clinical parameters for their prompt management that may prevent HAI and prolonged hospital stay.

Quality of life of down syndrome children with gastrointestinal disorders using pediatric quality of life inventoryTM (PedsqlTM) assessment

“…A total of 3 subjects experienced diarrhea (3%). Das et al (2015) stated that Down syndrome children in developing countries always experience malnutrition (Das et al, 2015;Valenzuela et al, 2011). In this study, 19 (18.8%) Down syndrome children were found to have constipation.…”

Genetic counseling in the context of Bangladesh: current scenario, challenges, and a framework for genetic service implementation

“…Down syndrome is the most frequently reported chromosomal disorder in Bangladesh [ 15 , 52 ]. Other reports include Patau syndrome [ 53 ], Turner syndrome [ 54 , 55 ], intersex disorders (absence of typical binary notions of male or female bodies, e.g., due to aneuploidy) [ 56 , 57 ], and Klinefelter syndrome [ 55 , 58 , 59 ].…”