Experience of Prostate Cancer Awareness Week

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

“…Lupron Depot, a well-established product in the market, was approved by FDA in 1998 as a lyophilized formulation, composed by leuprorelin acetate-loaded PLGA or PLA microspheres. [91] This strategy was investigated and developed in order to avoid daily injections of leuprorelin acetate (gonadotropin-releasing hormone agonist) in the palliative treatment of advanced prostatic cancer, since microspheres allow a sustained release. Lupron Depot is available in four formulations for 1, 3, 4, and 6 months administration.…”

How did the PSA system arise?

“…Testing over three million men in the first decade of its existence, PCAW became the largest cancer screening programme in the USA. 10 Whereas the first trial of mammography -the Health Insurance Plan of Greater New York (HIP) trial, considered the first RCT in cancer screeningdates to 1963, randomized trials of PSA were initiated only in the 1990s. When PSA testing began there was, therefore, no body of evidence showing that it reduced mortality, which made it a sort of experiment on the male population, albeit without the constraint of informed consent that would operate in an actual experiment.…”

“…By 1992, when the American Cancer Society endorsed PSA, free tests were being offered at 1800 clinics. Testing over three million men in the first decade of its existence, PCAW became the largest cancer screening programme in the USA 10 …”