2014
DOI: 10.1016/j.neuropharm.2013.02.016
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Experience-dependent homeostatic synaptic plasticity in neocortex

Abstract: The organism’s ability to adapt to the changing sensory environment is due in part to the ability of the nervous system to change with experience. Input and synapse specific Hebbian plasticity, such as long-term potentiation (LTP) and long-term depression (LTD), are critical for sculpting the nervous system to wire its circuit in tune with the environment and for storing memories. However, these synaptic plasticity mechanisms are innately unstable and require another mode of plasticity that maintains homeostas… Show more

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Cited by 56 publications
(54 citation statements)
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“…The reduction in excitatory synaptic strength was in contrast to a global increase in the strength of excitatory synapses observed in deprived V1, which may indicate a homeostatic adaptation to increased activity in the spared sensory cortices (Whitt et al, 2013). Therefore, we examined whether the feed-forward TC inputs to A1 are altered cross-modally, and how this impacts A1 neuronal properties in the TC recipient layer 4 (L4).…”
Section: Introductionmentioning
confidence: 94%
“…The reduction in excitatory synaptic strength was in contrast to a global increase in the strength of excitatory synapses observed in deprived V1, which may indicate a homeostatic adaptation to increased activity in the spared sensory cortices (Whitt et al, 2013). Therefore, we examined whether the feed-forward TC inputs to A1 are altered cross-modally, and how this impacts A1 neuronal properties in the TC recipient layer 4 (L4).…”
Section: Introductionmentioning
confidence: 94%
“…Structural and functional remodeling of the circuitry takes place through activity-dependent synaptic maturation (Doll and Broadie, 2014; West and Greenberg, 2011). In addition to synaptic pruning, there are changes in synaptic size and strength at individual synapses (Whitt et al, 2014). …”
Section: Neurobiological Framework For Cognitive Function: Pfcmentioning
confidence: 99%
“…These compensatory changes occur across the entire distribution of the cell's miniature postsynaptic current (mPSC) amplitudes by a multiplicative scaling factor. Scaling is typically observed and studied in vitro, but has been described to a lesser extent in vivo in the spinal cord (Gonzalez-Islas and Knogler et al, 2010; and visual system (Desai et al, 2002;Goel et al, 2006;Whitt et al, 2014).…”
Section: Introductionmentioning
confidence: 99%