Regional feed supplies in Yakutia include hay stocks, succulent feeds, as well as own production and import of concentrated feeds to the republic. Main winter feeds include hay, silage, and haylage; in summer grass of natural pastures is available. Annual provision of livestock with nutrients reaches 60-65% of normal, which is a limiting factor for the development of the genetic potential of local cattle breeds in Yakutia. Understanding of general patterns in digestive processes and physiological and biochemical mechanisms of assimilation of nutrients was based on the results of the studies of domestic ruminant animals (cattle, sheep). Issues of increasing feed security remain urgent for agro-industrial production. The authors describe in detail a method of obtaining a protein-vitamin concentrate having pharmacological properties. Most of these processes involve gas components, liquid or solid substances. Complex hydrodynamic, thermal, and mass exchange processes occur simultaneously in fermenters. A method for expanding the production of feed protein using a combination of hydrodynamic and mass transfer characteristics and parameters with simultaneous optimization of the fermenter design and its operation modes is proposed, taking into account minimum energy consumption for oxygen dissolution and biomass production, based on technical capacity. Various types of devices are currently available; basically, they provide oxygen supply, as it is an integral part of device design, for the cultivation of microorganisms based on microbial synthesis. It should be emphasized that a fermenter is the main device of any microbiological production and largely determines its economic effectiveness. The obtained results will allow considerable acceleration of finalizing works for the development and improvement of perspective fermenter designs.