Experience and BCC subtypes as determinants of MAL-PDT response: Preliminary results of a national Brazilian project

Non-Invasive Treatment of Extensive Eyelid Cancerous Lesion by Photodynamic Therapy: A Case Report

“…The inflammatory process occurring after seven days following the first PDT session is observed in Figure 1, panel B, which is characterized by enhanced expression of pro-inflammatory cytokines and leukocyte infiltration [16]. Many studies on the efficacy of PDT on BCC have been published [4,17,18]. However, only few studies have reported on the topical application of PDT for the treatment of BCC of eyelid cancer [19,20].…”

“…Photodynamic therapy (PDT) is a noninvasive treatment that has shown high remission rates for several BCC's cases with excellent results when applied in the early stage of skin cancer [4]. In addition, PDT is a technically simple and noninvasive procedure that offers high level of efficacy and patient satisfaction.…”

Clinical Photodynamic Therapy Review and the Brazilian Experience

“…The program provided skin cancer treatment, improving public health system patients' welfare by making available health treatment with the latest technology [64,65] . Since then, more than 2 000 lesions have been treated at about 100 treatment centers established by this program, in Brazil -(distribution by country region: North: 1.8%, Central-West: 5.6%, Northeast: 13.2%, South: 30.6%; Southeast 48.8%) -and Latin America (5.2% of them), and particularly by the Phototherapy and Photodiagnosis center at the AmaralCarvalhoHospital Foundation (Jahu-SP, Brazil), a region reference hospital which treats usually more than 70 000 cancer patients a year, and which is a main training center for upcoming treatment centerswith the national devices and drug provided under the program [66][67][68][69] .…”

Clinical Protocol Standardized in a Public Health System Using a Prototype for Actinic Keratosis and Field Cancerization Treatment

“…This therapy is based on three basic elements: the presence of a photosensitizer, a drug that absorbs light to trigger a series of chemical reactions; light at an appropriate wavelength, and the molecular oxygen present in the tissue to be treated, which reacts with the activated drug resulting in reactive oxygen species that are capable of inducing the cellular tissue necrosis, with subsequent re-epithelialization [18] . Our research group has a long experience in clinical trials using PDT for the treatment of non-melanoma skin cancer [19] , onychomycosis [20] , condyloma and cervical intraepithelial neoplasia [21] . PDT allows treatment of a large extension of skin, achieving both subclinical and clinical lesion, less aggressively and more efficiently, with good aesthetic outcome.…”