Clinical Protocol Standardized in a Public Health System Using
a Prototype for Actinic Keratosis and Field Cancerization
Treatment

Sálvio, Ana Gabriela; Oliveira, Elisangela Ramos de; Ramirez, Dora Patricia; Blanco, Kate Cristina; Inada, Natália Mayumi; Kurachi, Cristina; Bagnato, Vanderlei Salvador

doi:10.17554/j.issn.1819-6187.2016.04.79

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…The red LED (660 nm) was applied emitting continuous waves and using the contact mode on wound center during 2 min. The parameters of irradiation were 150 mW power, 0.5 cm 2 spot area, 300 mW/cm 2 intensity, 18 J energy and 36 J/cm 2 dose [16].…”

Section: Methodsmentioning

confidence: 99%

Photobiomodulation and photodynamic therapy applied after electrocauterization for skin healing optimization in rats

Manoel

Mariano

Ramos

et al. 2022

Journal of Biophotonics

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Photobiomodulation-PBM and Photodynamic Therapy-PDT have been used to induce healing. However, the effects of these therapies on skin-lesions induced by electrocautery are unknown, aiming at more favorable clinical and esthetic results. Electrocauterization was done in 78-female Wistar-rats using a system that includes an electrocautery and red-LED. The groups were: No injury, Injury, Injury + ALA (topical 5-aminolevulinic acid application), Injury + LED and Injury + ALA + LED (topical ALA application followed by photoactivation with LED). After 2nd, 7th and 14th days post-injury, immuno-histomorphometric analyses (inflammatory infiltrate, blood vessels, fibroblasts, eschar/epidermal thickness, IL-10 and VEGF) and biochemical assays of MPO (neutrophil), NAG (macrophage), nitrite, DCF (H 2 O 2 ), carbonyl (membrane's damage), sulfhydryl (membrane's integrity), SOD, GSH, hydroxyproline and re-epithelialization area were performed. The Injury + LED and Injury + ALA + LED groups controlled inflammation and oxidative stress, favoring angiogenesis, fibroblasts proliferation and collagen formation.

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Section: Methodsmentioning

confidence: 99%