Expediting Image Acquisition in Reflection Ultrasound Computed Tomography

Lafci, Berkan; Robin, Justine; Deán‐Ben, Xosé Luís; Razansky, Daniel

doi:10.1109/tuffc.2022.3172713

Cited by 9 publications

(16 citation statements)

References 42 publications

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“…1c. RUCT imaging was based on the synthetic transmit aperture (STA) image acquisition technique [25], which employs sequential transmission of US pulses with each array element followed by detection of the reflected signals. Image compounding was subsequently performed by adding up multiple low-contrast delay-and-sum images acquired from different views around the sample, resulting in a final high-contrast RUCT images (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…While the achieved frame rates were generally sufficient for the experiments performed in this work, a high temporal resolution may be required to quantify dynamic biological processes, such as contrast-enhanced imaging for better assessment of NAFLD. The frame rate of all the TROPUS modalities can be increased by compressed sensing methods [26], [41] or optimized data acquisition strategies [25]. Deep learning-based methods could further enhance the performance of sparse acquisition strategies and provide more accurate segmentation of the liver boundaries [42], [43].…”

Section: Discussionmentioning

confidence: 99%

“…The acquisition scheme thus resulted in 512×512 time-resolved signals for the 512 transmission events. Cross-sectional images from single transmission events were reconstructed individually using delay and sum (DAS) algorithm [25]. It combines the information contained in 128 neighboring channels (90°) around the transmitting element to reconstruct a low-contrast RUCT image from each individual transmission event.…”

Section: Methodsmentioning

confidence: 99%

“…RUCT imaging was based on the STA image acquisition technique [25]. Data acquisition was performed by sequential transmission of a single-cycle bipolar square US wave (0.16 µs, 38 Vpp) with each array element.…”

Section: Reflection Ultrasound Computed Tomography (Ruct) Imagingmentioning

confidence: 99%

“…Recently, a multi-modal transmission-reflection optoacoustic ultrasound (TROPUS) imaging has been suggested as a versatile imaging approach for multi-parametric anatomical, functional and molecular characterization of murine disease models [23], [24]. The full tomographic coverage of the circular transducer array used in TROPUS results in an improved contrast and resolution with MSOT, RUCT and TUCT, while further providing real-time imaging capabilities for visualizing dynamic processes [25], [26]. Here, we employed TROPUS for assessing early-stage NAFLD in mice.…”

Section: Introductionmentioning

confidence: 99%

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Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound

Lafci

Hadjihambi

Konstantinou

et al. 2022

Preprint

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Non-alcoholic fatty liver disease (NAFLD) is an umbrella term referring to a group of conditions associated to fat deposition and damage of liver tissue. Early detection of fat accumulation is essential to avoid progression of NAFLD to serious pathological stages such as liver cirrhosis and hepatocellular carcinoma. We exploited the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS), which combines the advantages of optical and acoustic contrasts, for an early-stage multi-parametric assessment of NAFLD in mice. The multispectral optoacoustic imaging allowed for spectroscopic differentiation of lipid content, as well as the bio-distributions of oxygenated and deoxygenated hemoglobin in liver tissues in vivo. The pulse-echo (reflection) ultrasound (US) imaging further provided a valuable anatomical reference whilst transmission US facilitated the mapping of speed of sound changes in lipid-rich regions, which was consistent with the presence of macrovesicular hepatic steatosis in the NAFLD livers examined with ex vivo histological staining. The proposed multimodal approach facilitates quantification of liver abnormalities at early stages using a variety of optical and acoustic contrasts, laying the ground for translating the TROPUS approach toward diagnosis and monitoring NAFLD in patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Reflection Ultrasound Computed Tomography (Ruct) Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound

Lafci

Hadjihambi

Konstantinou

et al. 2022

Preprint

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Multilayer Polymer Shell Perfluoropentane Nanodroplets for Multimodal Ultrasound, Magnetic Resonance, and Optoacoustic Imaging

Maksimova

Nozdriukhin

Kalva

et al. 2023

Laser & Photonics Reviews

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Multimodal imaging increases the value of stand‐alone modalities by enabling simultaneous multiparametric characterization of biological tissues in vivo. Particularly, optoacoustic (OA) tomography has enabled bringing optical imaging advantages to previously unattainable depths and is currently being hybridized with other imaging technologies for enhanced performance. The full potential of these multimodal imaging approaches can only be achieved with dedicated contrast agents ensuring simultaneous measurements and accurate co‐registration of the information provided. Herein, perfluoropentane‐filled nanodroplets are modified, providing excellent contrast in ultrasound imaging, by introducing shell‐embedded additives offering strong contrast in magnetic resonance and OA imaging. Magnetite nanoparticles and indocyanine green (ICG) dye are simultaneously deposited as a multilayer shell on the droplets with the layer‐by‐layer method. This results in sufficiently high amounts of magnetite (0.54 ± 0.08 mg mL−1) and ICG (0.30 ± 0.08 mg mL−1) for efficient magnetic resonance and OA detection, respectively. The high sensitivity achieved with the developed trimodal nanodroplets is first demonstrated in phantom experiments, after which their potential toxic effects, biodistribution, and clearance are examined in vitro and in vivo. Taken together, the obtained results indicate that the developed multilayer polymer shell nanodroplets are efficient hybrid contrast agents for multimodal biomedical imaging applications.

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Real-time assessment of high-intensity focused ultrasound heating and cavitation with hybrid optoacoustic ultrasound imaging

et al. 2023

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Expediting Image Acquisition in Reflection Ultrasound Computed Tomography

Cited by 9 publications

References 42 publications

Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound

Multimodal Assessment of Non-Alcoholic Fatty Liver Disease with Transmission-Reflection Optoacoustic Ultrasound

Multilayer Polymer Shell Perfluoropentane Nanodroplets for Multimodal Ultrasound, Magnetic Resonance, and Optoacoustic Imaging

Real-time assessment of high-intensity focused ultrasound heating and cavitation with hybrid optoacoustic ultrasound imaging

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