Expansion of activated eosinophils in infants with severe atopic dermatitis

Abstract

Evaluation of eosinophil activation and early therapeutic intervention is mandatory for the treatment of severe AD during infancy.

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets

“…62 In AD, its expression on eosinophils was associated with high IgE levels and active inflammation, 63 and data from other allergic diseases indicate that CD69 promotes the inflammatory process. 64 Our data show that CD69 is the only activation marker higher in children vs. adults with AD.…”

Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome

“…Although our case before prednisolone (1.5 mg/kg/day) treatment presented with marked hypereosinophilia (21 800/µL) almost 50 times higher than that in disease control, namely, acute asthma (4.0 ± 0.4 years old), the eosinophil cationic protein (ECP) level was almost comparable to that of acute asthma (eosinophil counts, 21 800 vs 442.3 ± 70.0/µL; ECP levels, 23.3 vs 30.2 ± 4.4 ng/mL), as shown in Table 1. Figure 1 shows that the expression of CD69, an activation marker of eosinophils, 4 on peripheral eosinophils in our case was minimal compared with a patient with severe atopic dermatitis as positive control. Serum concentrations of T helper (Th)2 cytokines including interleukin (IL)‐4 and IL‐13 before treatment were markedly elevated compared with those of acute asthma (IL‐4, 78.9 vs 26.2 ± 4.2; IL‐13, 99.8 vs 5.1 ± 0.8 pg/mL).…”

Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

“…Interestingly no association was found with either sex, however many studies have reported males to have raised IgE levels [49]. According to Toma et al [50], infants suffering from severe allergic diseases have significantly higher number of eosinophils and eosinophilic nuclear lobes, platelets, and total serum IgE level. Studies over the past 2 decades have shown that eosinophils play a major role in allergic diseases, characterized by activated eosinophils in the peripheral blood and in the lesional skin [51].…”