Expanding the repertoire of aromatic chemicals by microbial production

Abstract

Microbial production of aromatic chemicals would greatly contribute to solving the problems with fossil resource supply and environmentally sustainable development. Engineering and extending the shikimate/aromatic amino acid biosynthetic pathways are important routes for microbial production of various aromatic chemicals. With advances in metabolic engineering and synthetic biology, we can broaden the product spectrum and obtain several valuable and novel aromatic chemicals from renewable feedstocks. Here, in this review, the latest research progress on microbial production of various aromatic chemicals, and recent metabolic engineering and synthetic biology strategies targeting the central carbon metabolism, the shikimate and aromatic amino acid biosynthetic pathways are summarized and discussed. This work aims to provide some valuable tips for the construction of cost‐effective engineered strains for producing various aromatic chemicals. © 2018 Society of Chemical Industry

Study on the Macro‐Kinetics of NO Advanced Oxidation Removal by Decomposition of Gas‐Phase H2O2 over γ‐Fe2O3@Fe3O4

“…From Figure 9, the O1s spectrum could be divided into three peaks, which were lattice oxygen (Olat = 529.6 ∼ 530.4 eV), adsorbed oxygen associated with hydroxyl or carbonate (Oad = 531.2 ∼ 532.2 eV), and adsorbed molecular water (H 2 O ∼ 532.2 eV). [27][28][29][30][31][32][33] The Table 5 exhibited the concentration of Oad/(Oad + Olat) in different catalysts. In our experimental system, the injection of hydrogen peroxide increased the humidity of flue gas, which converted surface carbonate groups into surface hydroxyl groups under high humidity conditions.…”

Enhanced 5‐aminovalerate production in Escherichia coli from l‐lysine with ethanol and hydrogen peroxide addition

“…To make such bio‐based processes competitive, microbial host strains have been metabolically engineered to improve the yield and productivity of various chemicals, including alcohols, amino acids, and plastics . It is expected that more chemicals and materials of petrochemical origin and industrial importance will be produced through bio‐based processes employing microorganisms developed by metabolic engineering and synthetic biology …”

Bioprocess Optimization for the Production of Aromatic Compounds With Metabolically Engineered Hosts: Recent Developments and Future Challenges

“…One of the main bottlenecks in the microbial production of aromatic compounds is the availability of the precursors PEP (produced during glycolysis) and E4P (derived from the pentose phosphate pathway -PPP) (Suástegui et al, 2016;Noda and Kondo, 2017;Averesch and Krömer, 2018;Wu et al, 2018). Different strategies have been described in order to engineer the central carbon metabolism into this direction (Leonard et al, 2005;Papagianni, 2012;Nielsen and Keasling, 2016).…”

“…Aromatic compounds are produced by microbial hosts via the shikimate pathway, which leads to the production of aromatic amino acids as well as other aromatic precursors (Herrmann, 1995;Maeda and Dudareva, 2012;Averesch and Krömer, 2018). This can be achieved by the functional reconstruction of naturally occurring pathways or by de novo pathway engineering (Dhamankar and Prather, 2011;Wu et al, 2018). Escherichia coli and Saccharomyces cerevisiae are the most commonly employed microorganisms for aromatic compound production.…”