Expanding the applications of microneedles in dermatology

Sabri, Akmal Hidayat Bin; Ogilvie, Jane; Abdulhamid, Khuriah; Shpadaruk, Volha; McKenna, John M.; Segal, Joel; Scurr, David J.; Marlow, Maria

doi:10.1016/j.ejpb.2019.05.001

Cited by 73 publications

(35 citation statements)

References 197 publications

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“…There are many benefits and challenges of translating the MNs as drug delivery systems into clinical practice. However, MNs have been widely studied and had demonstrated flexibility in the application in treating several dermatological conditions [69].…”

Section: Resultsmentioning

confidence: 99%

Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution

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Vollet‐Filho

et al. 2020

Journal of Biophotonics

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One important limitation of topical photodynamic therapy (PDT) is the limited tissue penetration of precursors. Microneedles (MNs) are minimally invasive devices used to promote intradermal drug delivery. Dissolving MNs contain drug-associated to polymer blends, dissolving after insertion into skin, allowing drug release. This study comprises development and characterization of a pyramidal model of dissolving MNs (500 μm) prepared with 5% wt/wt aminolevulinic acid and 20% wt/wt Gantrez AN-139 in aqueous blend. Protoporphyrin IX formation and distribution were evaluated in tumor mice model by using fluorescence widefield imaging, spectroscopy, and confocal microscopy. MNs demonstrated excellent mechanical resistance penetrating about 250 μm with minor size alteration in vitro, and fluorescence intensity was 5-times higher at 0.5 mm on average compared to cream in vivo (being 10 ± 5 a.u. for MNs and 2.4 ± 0.8 a.u. for cream). Dissolving MNs have overcome topical cream application, being extremely promising especially for thicker skin lesions treatment using PDT.

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Section: Resultsmentioning

confidence: 99%

Dissolving microneedles containing aminolevulinic acid improves protoporphyrin IX distribution

Requena

Permana

Vollet‐Filho

et al. 2020

Journal of Biophotonics

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“…First of all, they are characterized by having possible allergic reactions in the case of metal MNs [13,14,76] and require specialized personnel and a complex pump-based set up for their injection [77]. Despite this, some studies recommend their applications in the dermatological field as well as in clinical applications for local and systemic delivery of drugs, vaccines, and cells [77][78][79].…”

Section: Hollow Mnsmentioning

confidence: 99%

Progress in Microneedle-Mediated Protein Delivery

Jamaledin

Natale

Onesto

et al. 2020

JCM

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The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

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“…Indirectly, this removes the need for cold chain storage and specialized transport systems, which has considerable impact in developing regions where cold chain storage facilities may be scarce. 31 Additionally, the reuse of hypodermic needles is an ongoing concern in developing regions. Most MNPs are disposable medical products without sharp biohazardous waste, and lower medical pollution is expected.…”

Section: Advantages Of Microneedlesmentioning

confidence: 99%