Progress in Microneedle-Mediated Protein Delivery

Jamaledin, Rezvan; Natale, Concetta Di; Onesto, Valentina; Taraghdari, Zahra Baghban; Zare, Ehsan Nazarzadeh; Makvandi, Pooyan; Vecchione, Raffaele; Netti, Paolo Antonio

doi:10.3390/jcm9020542

Cited by 92 publications

(70 citation statements)

References 155 publications

(232 reference statements)

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“…On the other hand, as mentioned before, resistance of cancer cells to chemotherapy is an increasing challenge in the field of cancer therapy. Hence, using carriers for protecting and delivering of biotherapeutic agents not only ameliorates its anti-tumor activity but also sensitizes cancer cells to the inhibitory effects of chemotherapeutic agents (Mahmoudi et al, 2019;Jamaledin et al, 2020).…”

Section: Apigenin-loaded Nanovehiclesmentioning

confidence: 99%

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

et al. 2020

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Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells via the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the hypoxia inducible factor (HIF), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1). Herein, the biotherapeutic activity of apigenin and its mechanisms toward cancer cells are presented in the current review to shed some light on anti-tumor activity of apigenin in different cancers, with an emphasis on pancreatic cancer.

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Section: Apigenin-loaded Nanovehiclesmentioning

confidence: 99%

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

et al. 2020

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“…Although curcumin possesses high toxic activity toward cancer cells, it suffers from some limitations such as light sensitivity and poor water solubility (N. Singh, Sachdev, & Gopinath, 2018). Accordingly, to enhance the solubility of hydrophobic drugs and accordingly utilize them in biomedical applications, for example, in drug delivery, different kind of microdevices and nanocarriers are used (Jamaledin et al, 2020; Jyoti et al, 2017; Moeini, Pedram, Makvandi, Malinconico, & d'Ayala, 2020). In light of this, to avail entire benefits of curcumin or at least overlook some of its drawbacks, curcumin‐encapsulated systems are being employed (Ibrahim, Tagami, Kishi, & Ozeki, 2018; L. Zhang et al, 2016).…”

Section: Curcumin and Lung Cancermentioning

confidence: 99%

Versatile role of curcumin and its derivatives in lung cancer therapy

Ashrafizadeh

Najafi

Makvandi

et al. 2020

Journal Cellular Physiology

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Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

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“…For a successful drug or other biomolecule delivery, a specific dose of drug/biomolecule should be delivered at the targeted site during a desired period [57,58]. Aside from polymeric membrane, one method can be used for modification of nanomaterials, e.g., polymeric or metallic nanoparticles, in which polymeric compounds are applied to control the drug release in human body.…”

Section: Drug Deliverymentioning

confidence: 99%

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

et al. 2020

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The use of polymers and nanomaterials has vastly grown for industrial and biomedical sectors during last years. Before any designation or selection of polymers and their nanocomposites, it is vital to recognize the targeted applications which require these platforms to be modified. Surface functionalization to introduce the desired type and quantity of reactive functional groups to target a cell or tissue in human body is a pivotal approach to improve the physicochemical and biological properties of these materials. Herein, advances in the functionalized polymer and nanomaterials surfaces are highlighted along with their applications in biomedical fields, e.g., antimicrobial therapy and drug delivery.

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Progress in Microneedle-Mediated Protein Delivery

Cited by 92 publications

References 155 publications

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Versatile role of curcumin and its derivatives in lung cancer therapy

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

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