Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Mohan, .; Anbalagan, Viknesh Prabu

doi:10.4103/2230-8210.107825

Cited by 42 publications

(36 citation statements)

References 23 publications

(37 reference statements)

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“…Using both urban and rural populations in India, investigators developed and validated the Indian Diabetes Risk Score (IDRS) to detect undiagnosed diabetes in Indians. 152 The score takes into account age, sex, waist circumference, physical activity and family history and can be calculated on-line (http://www.drmohansdiabetes.com/), with a score of ≥ 60 out of 100 considered high risk. 152 This score has not been tested against other existing diabetes risk scores.…”

Section: Detection and Prevention Of Diabetes In South Asiansmentioning

confidence: 99%

“…152 The score takes into account age, sex, waist circumference, physical activity and family history and can be calculated on-line (http://www.drmohansdiabetes.com/), with a score of ≥ 60 out of 100 considered high risk. 152 This score has not been tested against other existing diabetes risk scores. However, one notable difference between the American Diabetes Association (ADA) risk score and the IDRS is that the IDRS uses waist circumference instead of BMI which is likely a better predictor of diabetes risk in South Asians.…”

Section: Detection and Prevention Of Diabetes In South Asiansmentioning

confidence: 99%

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Diabetes and Associated Complications in the South Asian Population

2014

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The increasing prevalence of diabetes in South Asians has significant health and economic implications. South Asians are predisposed to the development of diabetes due to biologic and lifestyle factors. Furthermore, they experience significant morbidity and mortality from complications of diabetes, most notably coronary artery disease, cerebrovascular disease and chronic kidney disease. Therefore, understanding the pathophysiology and genetics of diabetes risk factors and its associated complications in South Asians is paramount to curbing the diabetes epidemic. With this understanding, the appropriate screening, preventative and therapeutic strategies can be implemented and further developed. In this review, we discuss in detail the biologic and lifestyle factors that predispose South Asians to diabetes and review the epidemiology and pathophysiology of microvascular and macrovascular complications of diabetes in South Asians. We also review the ongoing and completed diabetes prevention and management studies in South Asians.

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Section: Detection and Prevention Of Diabetes In South Asiansmentioning

confidence: 99%

Section: Detection and Prevention Of Diabetes In South Asiansmentioning

confidence: 99%

Diabetes and Associated Complications in the South Asian Population

2014

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“…According to International Diabetes Federation, diabetes currently affects 366.0 million people worldwide. India has the largest number of people with diabetes which is about 62.4 million (Mohan and Anbalagan 2013). Increase in the incidence of diabetes mellitus is mainly due to the modern life style and changing dietary patterns with balance tilted towards fabricated foods rich in sugar and fats.…”

Section: Introductionmentioning

confidence: 99%

Effect of modified atmospheric packaging on chemical and microbial changes in dietetic rabri during storage

et al. 2013

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Rabri is a dairy based sweet popular in the Indian subcontinent. The high sugar and fat content impose restrictions on its consumption due to health reasons. Dietetic rabri was prepared by the replacement of sugar with aspartame. Inulin was added to partially replace the milk fat and to improve the consistency of rabri. The rabri samples were packed in the polyethylene bags filled with different gaseous compositions (Air, 50 % CO2:50 % N2 and 100 % N2) and stored at 10°C. The shelf life was evaluated on the basis of changes in the chemical quality parameters such as HMF, TBA and FFA and microbial content such as total plate count, yeast and molds and coliform counts. The chemical parameters and microbial spoilage increased in all the samples with the progression of storage period. The samples packed with air showed significantly higher chemical deterioration and microbial spoilage as compared to the other two combinations. The samples packed with 100 % N2 were more shelf stable than with air and 50 % CO2:50 % N2 combinations.

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“…Insulin levels decline and hyperglycaemia ensues (Reaven 2004). Based on existing data, type 2 diabetes accounts for around 90%-95% of all diagnosed cases of diabetes mellitus worldwide (Mohan & Anbalagan 2013;Shaw, Sicree & Zimmet 2010;Uma & Sudarsanam 2012). At present, only insulin and oral antihyperglycaemic drugs are available for the management of diabetes (Lorenzati et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and anti-oxidant activities of the methanol leaf extract of <i>Vernonia amygdalina</i> in alloxan-induced diabetes in Wistar rats

Adeoye

Oyagbemi

Adedapo

et al. 2017

JOMPED

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The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p < 0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p < 0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.

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Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Cited by 42 publications

References 23 publications

Diabetes and Associated Complications in the South Asian Population

Diabetes and Associated Complications in the South Asian Population

Effect of modified atmospheric packaging on chemical and microbial changes in dietetic rabri during storage

Antidiabetic and anti-oxidant activities of the methanol leaf extract of <i>Vernonia amygdalina</i> in alloxan-induced diabetes in Wistar rats

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