Expanding Horizons of Cellular Plasticity in Regenerative Medicine

Sen, Chandan K.

doi:10.1016/j.ajpath.2015.06.003

Cited by 5 publications

(5 citation statements)

References 37 publications

(23 reference statements)

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“…Mϕ are highly plastic and respond to environmental cues by adapting to classically activated (M1) proinflammatory or alternatively activated (M2) anti-inflammatory, pro-angiogenic phenotype (62-63). Efferocytosis serves as a cue for mϕ switching to an anti-inflammatory and pro-angiogenic (M2) phenotype (7, 10-11, 31, 64-65).…”

Section: Discussionmentioning

confidence: 99%

Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes

Das

Ghatak

Sinha

et al. 2016

The Journal of Immunology

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109

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Milk fat globule EGF factor 8 (MFG-E8) is a peripheral glycoprotein which acts as a bridging molecule between the macrophage and apoptotic cells thus executing a pivotal role in the scavenging of apoptotic cells from affected tissue. We have previously reported that apoptotic cell clearance activity or efferocytosis is compromised in diabetic wound macrophages. In this work we test the hypothesis that MFG-E8 helps resolve inflammation, supports angiogenesis and accelerates wound closure. MFG-E8−/− mice, displayed impaired efferocytosis associated with exaggerated inflammatory response, poor angiogenesis and wound closure. Wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis. Transplantation of MFG-E8−/− bone marrow to MFG-E8+/+ mice resulted in impaired wound closure and compromised wound vascularization. On the other hand, MFG-E8−/− mice that received wild-type bone marrow showed improved wound closure and improved wound vascularization. Hyperglycemia and exposure to advanced glycated end products inactivated MFG-E8 recognizing a key mechanism that complicates diabetic wound healing. Diabetic db/db mice suffered from impaired efferocytosis accompanied with persistent inflammation and slow wound closure. Topical rMFG-E8 induced resolution of wound inflammation, improvements in angiogenesis and acceleration of closure upholding the potential of MFG-E8 directed therapeutics in diabetic wound care.

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Section: Discussionmentioning

confidence: 99%

Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes

Das

Ghatak

Sinha

et al. 2016

The Journal of Immunology

Self Cite

109

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“…The micro RNAs in human pathology: clinical utility and translational approach Jorge Luis Vélez 1 , Pablo Morocho 2 , Mario Montalvo 3 , Santiago Aguayo 3 , Pablo Andrés Vélez 4 , Gustavo Velarde 2 , Fernando Jara 3 , César Paz y Miño 5…”

Section: Los Micro Arns En Patología Humana: Utilidad Clínica Y Enfoque Traslacionalmentioning

confidence: 99%

“…Son ARNs pequeños (19 a 24 nucleótidos), no codificantes y no modificados desde el punto de vista evolutivo y cada miARN tiene el potencial de afectar a 500 genes 4 ; su papel fisiológico fundamental es la de reprimir genes implicados en la proliferación, apoptosis y diferenciación celular 5 , consecuentemente 'silenciamiento de la expresión genética'.…”

Section: Introductionunclassified

The micro RNAs in human pathology: clinical utility and translational approach

Vélez

Morocho

Montalvo³

et al. 2020

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In human clinics, pathologies as diverse as cancer, sepsis, autoimmune diseases, among others; of different etiology and a different pathophysiological behavior, converge in a failure of gene repression that allows the phenotypic expression of the disease; The possibility of having a biological marker that shows these events to the clinician is desirable since it would allow early diagnostic and therapeutic strategies. Micro RNAs are small and non-coding RNAs that fulfill that “genetic silencing” role, however, the step from basic research to clinical applicability, that is, their translational utility is still little diffused in specialties other than oncology. The objective of this review is to explain in a more precise way.

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“…Therapeutic SCs are a key component of regenerative medicine; they have the ability to differentiate into many different cell types and tissues and thus, can be utilized for numerous clinical applications, including tissue regeneration [5]. Hematopoietic SCs (HSC) transplantation, in which autologous or allogeneic HSCs are collected from bone marrow and injected into a patient in order to restore healthy immune system, is a well-established procedure [6].…”

Section: Therapeutic Application Of Scsmentioning

confidence: 99%