“…According to The John Hopkins Experience, only 55% patients who met the criteria for RP had tumors that were organ confined, and in approximately 10% of cases the disease involved regional lymph nodes or seminal vesicles. 97 Correlation of cytological grading with the Gleason score has been published elsewhere 59,63,67,70,72,[77][78] and the accuracy of digitally guided transrectal FNA has been tested in comparative studies with thick and ultrasound-guided thinneedle core biopsies; both methods have equal sensitivity and specificity, and false positives are rare to nonexistent: 7,8,[15][16]27,30,[32][33]36,[55][56]59,[61][62][68][69]71,73,76,92,93,95 FNA passed this scrutiny with honors and was deemed suitable to perform a confident diagnosis of prostate cancer. According to Tannenbaum,78 when an appropriate number of samples are obtained from palpable abnormal prostates, the detection rate for cancer is the same for both aspiration and core biopsies.…”