To assess clinical results in patients undergoing implantation of expanded polytetrafluoroethylene (Softform) for perioral enhancement (melolabial fold, melomental fold, upper lip, and lower lip). Design: Fifty patients had undergone Softform implantation by a single surgeon. A retrospective telephone survey (25 questions) was conducted. Of 50 patients, 38 (76%) were contacted. The mean interval between the procedure and survey was 22.7 months (range, 2-40 months). Responses were submitted for statistical analysis. A pathological review was performed on specimens removed from 2 patients. Results: Two patients (4%) developed postoperative infections that resolved with use of oral antibiotics; 5 patients (10%) requested repositioning owing to dissatisfaction with placement; and 5 patients (10%) requested implant removal. Composite scores indicated that patients were "slightly" satisfied with the procedure outcome. Of the 38 patients contacted, 24 (63%) would undergo additional implants and 20 (53%) would recommend the procedure to others. Results were not significantly influenced by site, size, or history of prior augmentation procedures. Histologic review indicated that implants elicit a chronic inflammatory reaction and that blood vessels infiltrate the porous walls of the implant. Conclusion: With proper patient selection, Softform represents a potential option for those individuals considering perioral enhancement.