Expanded Diagnostic Approach to Hepatitis E Virus Detection in Patients with Acute-on-Chronic Liver Failure: A Pilot Study

Steve, Runal John; Gnanadurai, Fletcher John; Raghavendran, Anantharam; Jeyaseelan, Visalakshi; Zachariah, Uday; Goel, Ashish; Chundamannil, Dr. Eapen  Eapen; Abraham, Priya

doi:10.4103/ijmm.ijmm_18_35

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…Minia university hospital with acute onset of unexplained deterioration in liver functions, in the period From December 2018 to December 2019. we aimed to detect HEV infection in patients with acute on chronic liver failure.In our study The underlying causes of liver disease was 29 cases (96.6%) due to infection with HCV and one case cryptogenic cirrhosis (3.33%) whileSteve RJ, et al, 2018 results were in contrast to our study with HCV 0%, cyptogenic 10, ethanol 60%(Steve et al, 2018).…”

contrasting

confidence: 67%

Hepatitis E virus infection in patients with acute on top of chronic liver diseases

Fouad

Sheemy

Ali

2020

Minia Journal of Medical Research

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Introduction: Acute on chronic liver failure (ACLF) characterized mainly by acute deterioration of underlying chronic liver disease. Hepatitis E virus (HEV) was reported as a precipitating event. Aim of the study: The aim of this study was to detect HEV infection in patients with acute on chronic liver failure. Materials & Methods: This is across sectional study conducted in Tropical department Minia university hospital in the period from December 2018 to December 2019. It included 30 patients with acute on chronic liver disorders, where blood samples were collected and HEV tested for anti-IgM and IgG by ELISA and then for HEV RNA by RT-PCR. Results: HEV RNA was detected in 13% of patients and IgG was positive in 26.7% of patients with acute on chronic liver failure. Discussion: HEV infection is a common cause in patients with chronic liver disease and presented with unexplained ACLF. Recommendation: based on the current study we recommend searching for HEV infection in patients with ACLF as one of our workup.

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confidence: 67%

Hepatitis E virus infection in patients with acute on top of chronic liver diseases

Fouad

Sheemy

Ali

2020

Minia Journal of Medical Research

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“…This is attributed to endemicity of HCV in Egypt. In contrast to Steve et al (8) , the findings of a prospective cross-sectional study conducted in India from January 2015 to August 2016 to assess the effect of HEV in ACLF patients; HCV was 0%, cryptogenic was 10%, and alcohol was 60 %.…”

Section: Discussionmentioning

confidence: 90%

Role of Acute Hepatitis E Virus Super Infection in Progression Stage of Liver Cirrhosis

2023

The Egyptian Journal of Hospital Medicine

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Background: Despite acute hepatitis E virus (HEV) infection is a self-limiting acute infection, it could be a cause of acute on top of chronic liver failure (ACLF) in patients with chronic liver disease. Thus, identification role of HEV superinfection in deterioration of liver cirrhosis with early treatment could save life of those patients. Aim: To determine the percentage and the role of HEV infection in order to detect outcomes of patients with ACLF, to find effect of HEV infection on liver, kidney functions and coagulation profile, and to find specific clinical or laboratory characteristics of these patients if present.

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“…Biological tests highlight elements of acute liver decompensation, such as increased bilirubin and aminotransferases, prolonged INR ≥ 1.5, anemia, thrombocytopenia, hypoglycemia, elevated serum ammonia, acute kidney injury (increased serum creatinine), and dyselectrolytemia (hypokalemia, hypophosphatemia, hyponatremia) [48,[80][81][82].…”

Section: Biological Evaluation and Imaging In Aclfmentioning

confidence: 99%

Challenges in Diagnosis and Therapeutic Approach of Acute on Chronic Liver Failure—A Review of Current Evidence

et al. 2023

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Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute and severe decompensation of chronic liver disease (CLD) correlated with multiple organ failure, poor prognosis, and increased mortality. In 40–50% of ACLF cases, the trigger is not recognized; for many of these patients, bacterial translocation associated with systemic inflammation is thought to be the determining factor; in the other 50% of patients, sepsis, alcohol consumption, and reactivation of chronic viral hepatitis are the most frequently described trigger factors. Other conditions considered precipitating factors are less common, including acute alcoholic hepatitis, major surgery, TIPS insertion, or inadequate paracentesis without albumin substitution. Host response is likely the primary factor predicting ACLF severity and prognosis, the host immune response having a particular significance in this syndrome, together with the inflammatory cascade. The management of ACLF includes both the prevention of the precipitating factors that lead to acute liver decompensation and the support of vital functions, the prevention and management of complications, the estimation of prognosis, and the opportunity for liver transplantation.

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Expanded Diagnostic Approach to Hepatitis E Virus Detection in Patients with Acute-on-Chronic Liver Failure: A Pilot Study

Cited by 7 publications

References 19 publications

Hepatitis E virus infection in patients with acute on top of chronic liver diseases

Hepatitis E virus infection in patients with acute on top of chronic liver diseases

Role of Acute Hepatitis E Virus Super Infection in Progression Stage of Liver Cirrhosis

Challenges in Diagnosis and Therapeutic Approach of Acute on Chronic Liver Failure—A Review of Current Evidence

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