Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

Bano, Afsareen; Vats, Ravina; Yadav, Pooja; Bhardwaj, Rashmi

doi:10.1016/j.critrevonc.2022.103799

Cited by 18 publications

(12 citation statements)

References 195 publications

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“…Recent research reveals a pivotal role for exosomes in ovarian function protection, offering a novel direction for the prevention and treatment of ovarian diseases [ 6 , 26 , 27 ]. Exosomes function significantly in cellular communication [ 28 , 29 ], disease progression, and immune regulation, with a particular emphasis on managing oxidative stress. Firstly, exosomes can extracellularly discharge antioxidant proteins, enzymes, and small-molecule antioxidants to eliminate oxidative stress products, thereby safeguarding damaged cells.…”

Section: Discussionmentioning

confidence: 99%

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway

Zhou,

Huang,

Zeng

et al. 2024

J Ovarian Res

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Background Chemotherapy exposure has become a main cause of premature ovarian insufficiency (POI). This study aimed to evaluate the role and molecular mechanism of human umbilical cord mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ovarian function protection after chemotherapy. Methods hUMSC-Exos were applied to cyclophosphamide-induced premature ovarian insufficiency mice and human ovarian granulosa tumor cells (KGN) to determine their effects on follicular development and granulosa cell apoptosis. Evaluation was done for iron ion and reactive oxygen species (ROS) production, lipid peroxidation levels, and changes in iron death-related molecules (nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Glutathione Peroxidase enzyme 4 (GPX4), and Solute carrier family 7 member 11 cystine glutamate transporter (SLC7A11; xCT)). Furthermore, rescue experiments using an Nrf2 inhibitor were performed to assess the therapeutic effects of hUMSC-Exos on granulosa cells. Results hUMSC-Exos promoted ovarian hormone levels and primary follicle development in POI mice and reduced granulosa cell apoptosis. After hUMSC-Exos treatment, the ROS production, free iron ions and lipid peroxidation levels of granulosa cells decreased, and the iron death marker proteins Nrf2, xCT and GPX4 also decreased. Furthermore, the Nrf2 inhibitor ML385 significantly attenuated the effects of hUMSC-Exos on granulosa cells. Conclusion hUMSC-Exos inhibit ferroptosis and protect against CTX-induced ovarian damage and granulosa cell apoptosis through the Nrf2/GPX4 signaling pathway, revealing a novel mechanism of hUMSC-Exos in POI therapy.

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Section: Discussionmentioning

confidence: 99%

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway

Zhou,

Huang,

Zeng

et al. 2024

J Ovarian Res

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“…In this context, the identification of subclasses of extracellular vesicles derived from cancer cells and microenvironmental components associated with well-defined pathological processes would allow them to serve as complementary biomarkers of circulating cfDNA and circulating tumor cells. In recent years, several studies have demonstrated the value of exosomes as cancer biomarkers, allowing longitudinal monitoring of tumor heterogeneity and early identification of cancer subtypes ( 154 , 155 ), as well as monitoring microenvironmental subversion ( 156 ), tumor progression and prognostic decisions ( 157 ), and response to therapy to tailor therapeutic interventions ( 158 , 159 ). Further developments in this field will bring us closer to the most important goal of providing personalized cancer care.…”

Section: Discussionmentioning

confidence: 99%

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Rao

Huang

et al. 2023

Front. Immunol.

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As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes are widely present in various body fluids, and therefore they can be used as a potential tool for non-invasive liquid biopsy. The present study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy as a first-line treatment for patients with NSCLC, this study also briefly describes the occurrence of EGRF+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.

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“…The direct interaction of saliva with tumors originating in the oral cavity positions act as the optimal medium for early detection and to monitor the response for the treatment of oral squamous cell carcinoma (OSCC) patients. These days, liquid biopsy has become a popular noninvasive cancer diagnosis technique. , Exosomes offer a few benefits over the alternative liquid biopsy process. ,, First, there is no need for treatments requiring large volumes of blood or urine because exosome concentrations are larger than those of CTCs. Second, exosomes exhibit remarkable circulation stability in contrast to ctDNA, which breaks down rapidly in the bloodstream. , As a result, new proteins and nucleic acids transported by exosomes have been proposed as novel diagnostic and prognostic indications for a range of cancer types .…”

Section: Exosome Source Of Oral Cancer Biomarkersmentioning

confidence: 99%

“…93,94 Exosomes offer a few benefits over the alternative liquid biopsy process. 165,167,181 First, there is no need for treatments requiring large volumes of blood or urine because exosome concentrations are larger than those of CTCs. Second, exosomes exhibit remarkable circulation stability in contrast to ctDNA, which breaks down rapidly in the bloodstream.…”

Section: Exosome Source Of Oral Cancer Biomarkersmentioning

confidence: 99%

Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

Kalele,

Nyahatkar,

Mirgh

et al. 2024

ACS Appl. Bio Mater.

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Exosomes are a subpopulation of extracellular vesicles (EVs) secreted by cells. In cancer, they are key cellular messengers during cancer development and progression. Tumor-derived exosomes (TEXs) promote cancer progression. In oral cancer, the major complication is oral squamous cell carcinoma (OSCC). Exosomes show strong participation in several OSCC-related activities such as uncontrolled cell growth, immune suppression, angiogenesis, metastasis, and drug and therapeutic resistance. It is also a potential biomarker source for oral cancer. Some therapeutic exosome sources such as stem cells, plants (it is more effective compared to others), and engineered exosomes reduce oral cancer development. This therapeutic approach is effective because of its specificity, biocompatibility, and cell-free therapy (it reduced side effects in cancer treatment). This article highlights exosome-based theranostics signatures in oral cancer, clinical trials, challenges of exosome-based oral cancer research, and future improvements. In the future, exosomes may become an effective and affordable solution for oral cancer.

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Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

Cited by 18 publications

References 195 publications

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway

Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway

Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

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