Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism

Xiao, Gui; Zhang, Haorui; Zhang, Rui; Li, Qing; Zhu, Weiye; Zheng, Na; Zhao, Jiawei; Cui, Xiao; Hao, Weiju; Wen, Xudong; Shen, Wei; Song, Hongyuan

doi:10.1016/j.mtbio.2023.100602

Cited by 8 publications

(11 citation statements)

References 57 publications

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“…Tube formation assay is widely used to assess angiogenic potential of ECs in vitro. 3 Our results showed that ESIONPs@EXO suppressed the tube formation ability of C166 significantly (Figure 4C,D). Cell migration and sprouting are the hallmarks for vascular expansion.…”

Section: Ferroptosis-inducing and Immuno-modulatory Properties Of Esi...mentioning

confidence: 55%

“…The data showed that ESIONPs@EXO suppressed the growth of C166 compared with Ctrl, ESIONPs and EXO groups (Figure A,B). Tube formation assay is widely used to assess angiogenic potential of ECs in vitro . Our results showed that ESIONPs@EXO suppressed the tube formation ability of C166 significantly (Figure C,D).…”

Section: Resultsmentioning

confidence: 71%

“…They are emerging as ideal vesicles for drug delivery, diagnosis, immunotherapy, and precision medicine . Engineering exosomes with nanomaterials is extensively studied to increase the therapeutic efficiency and decrease the toxicity of nanomaterials. − However, the current engineering methods (e.g., sonication or electroporation) cannot avoid damaging exosomal membrane and bioactive molecule inside. − In the present work, the concept of cell bioreactor assisted exosome modification with nanomaterials is proposed. Exosomes derived from different cells usually exhibit different therapeutic functions.…”

mentioning

confidence: 99%

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Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy

Zhang,

Mao,

Nie

et al. 2024

ACS Nano

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Engineering exosomes with nanomaterials usually leads to the damage of exosomal membrane and bioactive molecules. Here, pathological angiogenesis targeting exosomes with magnetic imaging, ferroptosis inducing, and immunotherapeutic properties is fabricated using a simple coincubation method with macrophages being the bioreactor. Extremely small iron oxide nanoparticle (ESIONPs) incorporated exosomes (ESIONPs@EXO) are acquired by sorting the secreted exosomes from M1-polarized macrophages induced by ESIONPs. ESIONPs@EXO suppress pathological angiogenesis in vitro and in vivo without toxicity. Furthermore, ESIONPs@EXO target pathological angiogenesis and exhibit an excellent T1-weighted contrast property for magnetic resonance imaging. Mechanistically, ESIONPs@EXO induce ferroptosis and exhibit immunotherapeutic ability toward pathological angiogenesis. These findings demonstrate that a pure biological method engineered ESIONPs@EXO using macrophages shows potential for targeted pathological angiogenesis therapy.

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Section: Ferroptosis-inducing and Immuno-modulatory Properties Of Esi...mentioning

confidence: 55%

Section: Resultsmentioning

confidence: 71%

mentioning

confidence: 99%

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Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy

Zhang,

Mao,

Nie

et al. 2024

ACS Nano

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“…Although neither nano-BPs generated structural damage on the aortic wall of C57BL/6 mice after intravenous injection at concentrations as high as 100 μg/mL, the transcriptome aberration in aortas triggered vasoconstrictive abnormalities, metabolic disturbances, and immune perturbations, suggesting the potential risks of nano-BPs on vasculature. Leveraging the antiangiogenic properties of nano-BPs, Song et al incorporated BPDs into Arg-Gly-Asp (RGD)-modified exosomes for the treatment of pathological retinal angiogenesis . The retinal angiogenesis was attenuated by disrupting glucose metabolism through the c-Myc/HK2 pathway.…”

Section: Cytotoxicity and Biological Responses Induced By Nano-bpsmentioning

confidence: 99%

“…Leveraging the antiangiogenic properties of nano-BPs, Song et al incorporated BPDs into Arg-Gly-Asp (RGD)-modified exosomes for the treatment of pathological retinal angiogenesis. 80 The retinal angiogenesis was attenuated by disrupting glucose metabolism through the c-Myc/HK2 pathway.…”

Section: Immunological Effectsmentioning

confidence: 99%

Recent Advances in the Biological Responses to Nano-black Phosphorus: Understanding the Importance of Intrinsic Properties and Cell Types

Zhao

Donskyi

Xiong

et al. 2023

Environ. Sci. Technol.

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The production scalability and increasing demand for nanoblack phosphorus materials (nano-BPs) inevitably lead to their environmental leakage, thereby raising the risk of human exposure through inhalation, ingestion, dermal, and even intravenous pathways. Consequently, a systematic evaluation of their potential impacts on human health is necessary. This Review outlines recent progress in the understanding of various biological responses to nano-BPs. Attention is particularly given to the inconsistent toxicological findings caused by a wide variation of nano-BPs' physicochemical properties, toxicological testing methods, and cell types examined in each study. Additionally, cellular uptake and intracellular trafficking, cell death modes, immunological effects, and other biologically relevant processes are discussed in detail, providing evidence for the potential health implications of nano-BPs. Finally, we address the remaining challenges related to the health risk evaluation of nano-BPs and propose a broader range of applications for these promising nanomaterials.

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Liu,

Tang,

Yin

et al. 2024

Advanced Science

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Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is of great significance. Combinational treatment modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against bacterial infections. Herein, red blood cell membrane fuses with macrophage membrane to develop hybrid cell membrane shell, which further camouflages around drug‐loaded liposome to fabricate biomimetic liposome (AB@LRM) for precise antibacterial therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) and classical antibiotics amikacin (AM) are loaded in AB@LRM to accurately target the inflammatory sites through the guidance of macrophage membrane and long residence capability of red blood cell membrane, eventually exerting efficacious antibacterial activities. Besides, due to the excellent photothermal and photodynamic properties, BPQDs act as an efficient antibacterial agent when exposed to near‐infrared laser irradiation, dramatically increasing the sensitivity of bacteria to antibiotics. Consequently, the synergistic sterilizing effect produced by AB@LRM further restricts bacterial resistance. Upon laser irradiation, AB@LRM shows superior anti‐inflammatory and antibacterial properties in models of P. aeruginosa‐infected pneumonia and wounds. Hence, this light‐activatable antibacterial nanoplatform with good biocompatibility presents great potential to advance the clinical development in the treatment of bacterial infections.

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Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism

Cited by 8 publications

References 57 publications

Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy

Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy

Recent Advances in the Biological Responses to Nano-black Phosphorus: Understanding the Importance of Intrinsic Properties and Cell Types

Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

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