“…In addition to their ability to cross the BBB, EV use is favorable because of low immunogenicity, biodegradability, and their non-toxic nature. Further, they can carry cargo, such as iron particles in this study and others 24,26,28,31,32,52,53 , as well as therapeutics 17,18,[20][21][22][23]25,50,51 . The mechanisms in which EVs cross the BBB is not fully understood; however, some possible routes which have been explored are micropinocytosis, clathrin-dependent endocytosis and caveolae-dependent endocytosis 15,16,54,55 .…”