Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives

Zhao, Kai; Li, Xiangyu; Shi, Yuanxin; Lü, Yun; Peng, Qiu; Deng, Zhengdong; Yao, Wei; Wang, Jianming

doi:10.1186/s12967-022-03294-x

Cited by 15 publications

(10 citation statements)

References 89 publications

(84 reference statements)

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“…According to previous research, TME plays a key role in the development of a variety of human cancers, 99 and exosomes are key components of TME that be isolated from various body fluids and contain specific RNAs, proteins or metabolites. These exosomes have a unique regulatory role in modulating TME.…”

Section: Discussionmentioning

confidence: 99%

Exosomes: Mediators in microenvironment of colorectal cancer

Yao

Chen

Lin

2023

Intl Journal of Cancer

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Tumor microenvironment, the soil where tumor thrives, plays a critical role in the development and progression of colorectal cancer (CRC). Various cell signaling molecules in the environment promote tumor angiogenesis, immune tolerance and facilitate immune escape. Exosomes, as messengers between tumor and host cells, are considered key mediators involved in the tumor-accelerating environment. However, the exosome-mediated communication networks in the CRC microenvironment are still largely unclear. In this review, we summarized the relationship between TME and CRC based on recent literature. Then, we revealed the unique impacts and signal molecules of exosomes on account of their regulatory role in the flora, hypoxia, inflammatory and immunological microenvironment of CRC. Finally, we summarized the therapeutically effective of exosomes in CRC microenvironment and discussed their current status and prospects, aiming to provide new molecular targets and a theoretical basis for the CRC treatment.

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Section: Discussionmentioning

confidence: 99%

Exosomes: Mediators in microenvironment of colorectal cancer

Yao

Chen

Lin

2023

Intl Journal of Cancer

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“…In the TME, complex intercellular communication occurs between various cell clusters, which jointly promote tumor progression (33). To gain insight into the relationship between TME and tumor cells in BTCs, we inferred the receptor-ligand interactions between them using the iTALK method (Fig.…”

Section: Receptor-ligand Interactions Between Tumor and Tme Cellsmentioning

confidence: 99%

Single-cell analysis reveals heterogeneity in the molecular profile of the tumor microenvironment of biliary tract cancers

Lai,

Mai,

Tsauo

et al. 2023

Preprint

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Background Biliary tract cancers (BTCs) are heterogeneous malignancies with diverse tumor microenvironment (TME) cells that contribute to tumor progression. However, the characteristics of the TME among different subtypes of BTCs remain unclear. Methods We integrated single-cell RNA sequencing data from BTC patients (iCCA, GBC, and eCCA) and RNA sequencing data from cholangiocarcinoma samples to construct a cellular molecular atlas of BTCs. Through enrichment analysis, we explored signaling pathways in tumor and TME cells, identified developmental trajectories and characterized transcription factors regulating different cell subpopulations using pseudotime analysis and gene regulatory network analysis. Moreover, we analyzed the intercellular communication between tumor cells and TME cells in different BTCs and developed a prognostic model. Results Malignant cells in different BTCs displayed significant heterogeneity, with variations in immune cell composition, biological functions, and metabolic pathways. Notably, the iCCA subpopulation demonstrated enhanced invasive potential, while the eCCA and GBC subpopulations showed significant activation of energy metabolism-related pathways. The carcinoma-associated fibroblast subpopulations in eCCA and GBC may regulate tumor cell metabolism through metabolic reprogramming, thereby facilitating tumor proliferation. GBC specifically exhibited enrichment of CXCL13 + tumor-reactive CD8 + T cells, indicating a potentially favorable response to immune checkpoint blockade therapy. Additionally, as tumor progression occurred, macrophage subpopulations in all three BTCs displayed M1/M2 dichotomous polarization, and the antigen-presenting ability of monocyte-derived dendritic cells gradually decreased. Conclusion This study analyzed single-cell landscape heterogeneity across BTC subtypes, revealing complex intercellular communication within the TME. A prognostic model was developed, providing insights for personalized precision medicine.

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“…Exosomes produced by tumor stem cells have been shown to be essential for tumor development and progression in recent years due to their ability to control TME elements locally or remotely in an autocrine or paracrine manner 15 . According to our study, the connection between CSC-Exos and TME is mainly re ected in the fact that exosomes regulate the growth and metastasis of tumor cells, participate in tumor angiogenesis and have potential value as tumor diagnostics [46][47][48][49] . In addition, it has also been shown that because CSC-Exos deliver key molecules that are responsive to chemotherapy and immunotherapy, they may also contribute to tumor drug resistance and impede effective responses to antitumor immunotherapy, leading to poor clinical outcomes 50,51 .…”

Section: The Hotspots and Frontiersmentioning

confidence: 99%

Global research trends in exosome tumor stem cells and tumor microenvironment: Visualization biology analysis

Guo,

Wang,

Jin

et al. 2023

Preprint

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The tumor microenvironment (TME) is an internal environment composed of various cells and an extracellular matrix. Cancer stem cells-derived exosomes (CSC-Exos), as essential messengers involved in various tumor processes, are important carriers for bidirectional communication between the tumor microenvironment and tumor cells and play an important role in the tumor microenvironment. Nevertheless, few bibliometric analyses have been systematically studied in this field. Therefore, we aimed to visualize the research hotspots and trends in this field through bibliometrics to comprehend the future evolution of fundamental and clinical research, as well as to offer insightful information and fresh viewpoints.The Scopus database was used to search the research literature related to exosomes and tumor microenvironments after the establishment of this repository. CiteSpace (version 5.8.R3) and VOSviewer (version 1.6.16) were used for visualization and analysis. In this study, a total of 2077 articles and reviews were included, with the number of articles on exosomes and tumor microenvironments significantly increasing yearly. Recent trends showed that the potential value of exosomes as “tumor diagnostics” and “the application prospect of exosomes as therapeutic agents and drug delivery carriers” will receive more attention in the future. We revealed the current status and hotspots of tumor stem cell-derived exosomes and tumor microenvironments globally through bibliometrics. The prospect of the regulatory role of CSC-Exos in TME, the potential value of diagnosis, and the application of drug delivery vectors will all remain cutting-edge research areas in the field of tumor therapy. Meanwhile, this study provided a functional literature analysis for related researchers.

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Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives

Cited by 15 publications

References 89 publications

Exosomes: Mediators in microenvironment of colorectal cancer

Exosomes: Mediators in microenvironment of colorectal cancer

Single-cell analysis reveals heterogeneity in the molecular profile of the tumor microenvironment of biliary tract cancers

Global research trends in exosome tumor stem cells and tumor microenvironment: Visualization biology analysis

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