Exosomes in cardiovascular diseases: a blessing or a sin for the mankind

Sharma, Shruti; Sharma, Ujjawal

doi:10.1007/s11010-021-04328-6

Cited by 12 publications

(14 citation statements)

References 130 publications

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“…While there have been several studies on GBM derived EVs, only a few have been conducted on MNG derived EVs (7–9, 18, 50, 51). A study by Ricklefs et al (2022) observed that the levels of circulating EVs in the blood of meningioma patients are increased, correlating with malignancy grade and oedema, but subsequently declined post-surgery (8).…”

Section: Discussionmentioning

confidence: 99%

Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

Su,

Purnianto,

Kaye

et al. 2024

Preprint

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Small extracellular vesicles have gained attention in neuroscience due to their role in cell-to-cell communication and their potential diagnostic and therapeutic applications. Despite progress in the field, there remains a gap in our understanding of the composition and function of extracellular vesicles with regards to brain tumours. Previous studies have primarily evaluated extracellular vesicles obtained from patient fluids or cell culture medium, rather than directly from tumour tissue. Here we successfully isolated small extracellular vesicles from surgical tissue biopsies of glioblastomas or meningiomas, marking, marking the first report of in situ extracellular vesicle isolation from brain tumours. The protein content of the tumour tissue and their extracellular vesicles was characterized using tandem mass spectrometric proteomics, revealing proteins exclusively detected or enriched in extracellular vesicles relative to the tumour tissue. While our study confirmed proteins previously identified in glioblastoma and meningioma extracellular vesicles from various sources, it also identified novel proteins and pathways associated with extracellular vesicles from these tumour types. This study underscores the benefit of analysing in situ extracellular vesicles derived directly from brain tissue for insights into tumour biology and highlights the need for further research comparing extracellular vesicles from various types and grades of brain tumours.

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Section: Discussionmentioning

confidence: 99%

Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

Su,

Purnianto,

Kaye

et al. 2024

Preprint

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“…112 Of these three proteins, SHH is the most expressed in mammals, and receptor complexes consisting of smoothened (SMO) and patched (PTCH1) proteins are present in this signaling pathway. 112,113 When the HH ligand binds to PTCH1, it suppresses SMO; therefore, the suppressed SMO then interacts with fused homologous suppressor protein (SUFU), activating the glioma-associated oncogene homolog (GL1) protein to activate target genes. 112,113 SMO mutations are seen in around 5.5% of grade 1 meningiomas without changes in NF2, TRAF7, KLF4, and AKT1 mutations.…”

Section: Targeting Hedgehog Pathway In Meningiomamentioning

confidence: 99%

“…56 Vismodegib and sonidegib are HH inhibitors that work by inhibiting the action of HH ligand cell surface receptors. 113 Vismodegib is studied in a phase II clinical trial under the number NCT02523014 with other drugs, including FAK inhibitor GSK2256098, Akt inhibitor capivasertib, and cyclin-dependent kinase inhibitor abemaciclib for progressive meningioma. 83 1.5.5 | Targeting Wnt pathway in meningioma…”

Section: Targeting Hedgehog Pathway In Meningiomamentioning

confidence: 99%

Related mechanisms, current treatments, and new perspectives in meningioma

Inetas‐Yengin,

Bayrak

2024

Genes Chromosomes & Cancer

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Meningiomas are non‐glial tumors that are the most common primary brain tumors in adults. Although meningioma can possibly be cured with surgical excision, variations in atypical/anaplastic meningioma have a high recurrence rate and a poor prognosis. As a result, it is critical to develop novel therapeutic options for high‐grade meningiomas. This review highlights the current histology of meningiomas, prevalent genetic and molecular changes, and the most extensively researched signaling pathways and therapies in meningiomas. It also reviews current clinical studies and novel meningioma treatments, including immunotherapy, microRNAs, cancer stem cell methods, and targeted interventions within the glycolysis pathway. Through the examination of the complex landscape of meningioma biology and the highlighting of promising therapeutic pathways, this review opens the way for future research efforts aimed at improving patient outcomes in this prevalent intracranial tumor entity.

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“…It was believed that, similarly functioning exosomes were involved in both normal physiological functions like wound repair, bone formation etc. [ [12] , [13] , [14] ], and pathological processes of thrombus induced disorders and certain autoimmune diseases [ [15] , [16] , [17] ]. Research studies in early 1980s have showed exosome secretion during differentiation of reticulocytes and also in seminal fluids that help in sperm maturation [ [18] , [19] , [20] ].…”

Section: Introductionmentioning

confidence: 99%