Exosome nanovesicles: A potential carrier for therapeutic delivery

Chavda, Vivek P.; Pandya, Anjali; Kumar, Lalit; Raval, Nidhi; Vora, Lalitkumar K.; Pulakkat, Sreeranjini; Patravale, Vandana; Salwa, -; Duo, Yanhong; Tang, Ben Zhong

doi:10.1016/j.nantod.2023.101771

Cited by 48 publications

(24 citation statements)

References 175 publications

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“…Furthermore, the isolation and analysis of exosome cargo hold promise for the early diagnosis and prognosis of pregnancy complications. Consequently, exosome vesicles show potential as diagnostic and prognostic tools during pregnancy. , …”

Section: Exosome Applicationsmentioning

confidence: 99%

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Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Altıntaş,

Saylan

2023

Anal. Chem.

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Extracellular vesicles (EVs) are crucial mediators of intercellular communication and can be classified based on their physical properties, biomolecular structure, and origin. Among EVs, exosomes have garnered significant attention due to their potential as therapeutic and diagnostic tools. Exosomes are released via fusion of multivesicular bodies on plasma membranes and can be isolated from various biofluids using methods such as differential ultracentrifugation, immune affinity capture, ultrafiltration, and size exclusion chromatography. Herein, an overview of different techniques for exosome characterization and isolation, as well as the diverse applications of exosome detection, including their potential use in drug delivery and disease diagnosis, is provided. Additionally, we discuss the emerging field of exosome detection by sensors, which offers an up-and-coming avenue for point-of-care diagnostic tools development. Overall, this review aims to provide a exhaustive and up-to-date summary of the current state of exosome research.

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Section: Exosome Applicationsmentioning

confidence: 99%

Section: Exosome Applicationsmentioning

confidence: 99%

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Altıntaş,

Saylan

2023

Anal. Chem.

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“…These are characterized by techniques like western blotting, microscopic techniques, nanoparticle tracking analysis, etc. [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although several advances in exosome-based research have been made in recent years, many challenges still remain, such as standard preparation and quality control procedures, as well as effective quantification methods for their comprehensive, and simultaneous inclusion. Several research activities are going under the umbrella of exosomes, ranging from manufacturing, purification, storage, quality control, modification, and their biological applications yet many are to be explored [ 8 ]. In this review, we aim to provide a comprehensive overview of exosomes, covering their composition, biogenesis, and isolation methods.…”

Section: Introductionmentioning

confidence: 99%

Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer

et al. 2023

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Background Exosomes are nanosized bio vesicles formed when multivesicular bodies and the plasma membrane merge and discharge into bodily fluids. They are well recognized for facilitating intercellular communication by transporting numerous biomolecules, including DNA, RNAs, proteins, and lipids, and have been implicated in varied diseases including cancer. Exosomes may be altered to transport a variety of therapeutic payloads, including as short interfering RNAs, antisense oligonucleotides, chemotherapeutic drugs, and immunological modulators, and can be directed to a specific target. Exosomes also possess the potential to act as a diagnostic biomarker in cancer, in addition to their therapeutic potential. Conclusion In this review, the physiological roles played by exosomes were summarized along with their biogenesis process. Different isolation techniques of exosomes including centrifugation-based, size-based, and polymer precipitation-based techniques have also been described in detail with a special focus on cancer therapeutic applications. The review also shed light on techniques of incubation of drugs with exosomes and their characterization methods covering the most advanced techniques. Myriad applications of exosomes in cancer as diagnostic biomarkers, drug delivery carriers, and chemoresistance-related issues have been discussed at length. Furthermore, a brief overview of exosome-based anti-cancer vaccines and a few prominent challenges concerning exosomal delivery have been concluded at the end. Graphical abstract

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“…Exosome-based delivery systems are also under different stages of development for cancer treatment. 23,24 The use of nanotheranostics in solid tumors, including drugs undergoing preclinical and clinical trials as well as current challenges and future issues, will be highlighted in this review. Arranja et al presented the fundamental concepts behind the utilization of nanoparticles for targeting tumors, emphasizing the advantages associated with incorporating imaging techniques to identify suitable patients and customize nanomedicine therapies.…”

Section: ■ Introductionmentioning

confidence: 99%

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

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Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.

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Exosome nanovesicles: A potential carrier for therapeutic delivery

Cited by 48 publications

References 175 publications

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

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