Exosome-modified PLGA Microspheres for Improved Internalization into Dendritic Cells and Macrophages

You, Gayeon; Kim, Young‐Jun; Lee, Joo Hang; Song, Jae Bok; Mok, Hyejung

doi:10.1007/s12257-020-0008-7

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…To fabricate hydrogel microspheres, water-in-oil emulsion is used. This is demonstrated by Liu et al, who developed chitosan microspheres after high-speed homogenization of acidified chitosan-liquid paraffin/petroleum ether/SPAN80 emulsion system [137] . With a diameter of 5 μm, the cationic charged spheres were incubated with anionic rabies virus glycoprotein peptide-modified EVs loaded with reactive oxygen species-responsive curcumin nanoparticles.…”

Section: Additional Functions Of Ev Delivery Systemsmentioning

confidence: 93%

Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

Chen¹,

Huang²,

Yang³

et al. 2022

Extracell Vesicles Circ Nucleic Acids

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The discovery and development of extracellular vesicles in tissue engineering have shown great potential for tissue regenerative therapies. However, their vesicle nature requires dosage-dependent administration and efficient interactions with recipient cells. Researchers have resorted to biomaterials for localized and sustained delivery of extracellular vesicles to the targeted cells, but not much emphasis has been paid on the design of the materials, which deeply impacts their molecular interactions with the loaded extracellular vesicles and subsequent delivery. Therefore, we present in this review a comprehensive survey of extracellular vesicle delivery systems from the viewpoint of material design at the molecular level. We start with general requirements of the materials and delve into different properties of delivery systems as a result of different designs, from material selections to processing strategies. Based on these differences, we analyzed the performance of extracellular vesicle delivery and tissue regeneration in representative studies. In light of the current missing links within the relationship of material structures, physicochemical properties and delivery performances, we provide perspectives on the interactions of materials and extracellular vesicles and the possible extension of materials. This review aims to be a strategic enlightenment for the future design of extracellular vesicle delivery systems to facilitate their translation from basic science to clinical applications.

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Section: Additional Functions Of Ev Delivery Systemsmentioning

confidence: 93%

Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

Chen¹,

Huang²,

Yang³

et al. 2022

Extracell Vesicles Circ Nucleic Acids

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“…In an interesting study, serum-derived exosomes were used to modify the surface of microspheres, not to target or to remove immunogenicity but to increase surface roughness ( You et al, 2020 ). High surface roughness of the MPs may facilitate phagocytosis due to the increased contact area and adhesive forces ( Champion, Walker and Mitragotri, 2008 ).…”

Section: Techniques Of Surface Modificationmentioning

confidence: 99%

“…XPS analysis penetration depth is about 10 nm, limiting its use to thin coatings ( Bao et al, 2018 ). You et al examined the XPS nitrogen peak at binding energy of 400 eV to confirm surface coating of exosomes on PLGA cores mediated by polydopamine ( You et al, 2020 ). After polydopamine functionalization, a new peak corresponding to amine groups of polydopamine was observed in the XPS spectrum.…”

Section: Characterization Of Surface Modificationmentioning

confidence: 99%

Recent advances in surface modification of micro- and nano-scale biomaterials with biological membranes and biomolecules

Abesekara

Chau

2022

Front. Bioeng. Biotechnol.

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Surface modification of biomaterial can improve its biocompatibility and add new biofunctions, such as targeting specific tissues, communication with cells, and modulation of intracellular trafficking. Here, we summarize the use of various natural materials, namely, cell membrane, exosomes, proteins, peptides, lipids, fatty acids, and polysaccharides as coating materials on micron- and nano-sized particles and droplets with the functions imparted by coating with different materials. We discuss the applicability, operational parameters, and limitation of different coating techniques, from the more conventional approaches such as extrusion and sonication to the latest innovation seen on the microfluidics platform. Methods commonly used in the field to examine the coating, including its composition, physical dimension, stability, fluidity, permeability, and biological functions, are reviewed.

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“…The rapid process of business globalization and intense competition in the environment encouraged companies to seek alternative opportunities outside their countries of origin [28,29]. Internationalization is considered a process of continuous growth, which must be seen as a phenomenon of advances and setbacks [30].…”

Section: Literature Review 21 Internationalizationmentioning

confidence: 99%

“…In line with the process of internationalization of companies, You et al [28], states that there are several motivations for internationalization. Internationalization is believed to increase profitability, improve performance, minimize insolvency, and improve investors' risk return opportunities [33].…”

Section: Literature Review 21 Internationalizationmentioning

confidence: 99%

Sustainable International Expansion via Cooperation Networks in the Manufacturing Industries

et al. 2021

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For the manufacturing industry in particular, networks lead to an increasing interaction between different actors representing a complementary response to insecurity arising from internationalization subjects. The aim of this study is to understand how cooperation networks contribute to the international sustainability of the manufacturing industry. To carry out this study, a qualitative methodology was chosen through semi-structured interviews with eight companies in the manufacturing sector from different areas. The interviews were handled with NVIVO software support. Regarding the findings, it is unanimous that cooperation networks are essential for the internationalization of the manufacturing industry. In general, the companies that participated in the study believe that the networks helped to reduce costs and to have access to certain resources that were essential for the success of internationalization. Furthermore, the findings suggest that the size of the country and the low purchasing power were some of the substantial factors that triggered the process of searching for new markets. It also became evident that there are barriers that need to be taken into account at the time of internationalization and that cooperation with other companies can help to overcome them. This study provides empirical evidence on the importance of cooperation networks for the internationalization of companies in the manufacturing industry. Furthermore, this study demonstrates the main motivations, strategies and barriers for these companies to internationalize.

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Exosome-modified PLGA Microspheres for Improved Internalization into Dendritic Cells and Macrophages

Cited by 15 publications

References 33 publications

Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level

Recent advances in surface modification of micro- and nano-scale biomaterials with biological membranes and biomolecules

Sustainable International Expansion via Cooperation Networks in the Manufacturing Industries

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