Exosome-Coated Metal–Organic Framework Nanoparticles: An Efficient Drug Delivery Platform

Illes, Bernhard; Hirschle, Patrick; Barnert, Sabine; Cauda, Valentina; Wuttke, Stefan; Engelke, Hanna

doi:10.1021/acs.chemmater.7b02358

Cited by 191 publications

(166 citation statements)

References 36 publications

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“…Different methods, used for MOFs surface coating to date comprise either physical adsorption or chemical association. The former exploits electrostatic interactions between the surface and the coating agent and occurs under desired mild conditions, which not only improves nanoMOFs' chemical and colloidal stability but also affects their circulating fate, providing properties such as stealth, targeting, or bioadhesion, without compromising the MOF porosity and therefore, its encapsulation/release capabilities. The second approach involves a selective grafting typically directed through click chemistry, condensation reactions, or chemical complexation, among others, ending with an even more stable surface coating, which also confers multiple properties such as stability, enhanced cytotoxicity, as well as long circulating properties or targeting.…”

Section: Introductionmentioning

confidence: 99%

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Giménez‐Marqués

Bellido

Berthelot

et al. 2018

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Controlling the outer surface of nanometric metal-organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL-100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF-PEG interaction is deeply investigated using high-resolution soft X-ray spectroscopy. Finally, a cell penetration study using the radio-labeled antitumor agent gemcitabine monophosphate ( H-GMP)-loaded MIL-100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness.

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Section: Introductionmentioning

confidence: 99%

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Giménez‐Marqués

Bellido

Berthelot

et al. 2018

Small

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“…Qi et al first integrated blood exosomes with superparamagnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 @exosome) for magnetic field‐controlled tumor‐targeting drug delivery . Illes et al first fabricated exosome‐coated metal‐organic framework nanoparticles (exosome@MOF) for enhanced drug delivery . Moreover, Betzer et al also integrated exosomes with gold nanoparticles (exosome@Au) for in vivo neuroimaging .…”

Section: Discussionmentioning

confidence: 99%

Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms

2018

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Recent marked technological advances in the field of exosome nanotechnology have provided unprecedented opportunities to bloom the developments of exosome-related biology, chemistry, pathology, and therapeutics, which have laid a solid basis for scientific community to design exosome-based nanotheranostic platforms. The unique structural/ compositional/morphological characteristics of exosomes as natural nanocarriers, as well as their fascinating physicochemical/biochemical properties, which underpin their special physiopathological roles, have triggered the concept that these cell-derived nanovesicles with intrinsic biological functions can be highly competent for the establishment of next-generation nanomedicine. Herein, efforts are made to give a comprehensive overview on the recent advances of exosome nanotechnology based on the representative examples of the current state of the art of exosome-based research, ranging from their formation, biological function, preparation, and characterization to their extensive nanomedical applications. It is highly expected that the better and clearer elucidation of the fundamental principles for advanced nanotechnology in constructing exosome-based theranostic nanoplatforms, as well as integrating the intrinsic advantages of exosomes as endogenous cell-derived nanocarriers with the advanced design methodology of traditional nanomedicine, will help to unlock the innate powers of exosomes for the establishment of nextgeneration theranostic nanoplatforms.

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“…Numerous strategies have been proposed so far to modify the surface of nanoMOFs using a large variety of molecules, such as nucleic acids, polymers, cyclodextrins (CDs), or lipids, resulting into various degrees of improvement of the particles properties. One can classify these approaches into three categories: covalent, noncovalent, ( Table 2 ) or core–shell, as detailed below.…”

Section: Surface Modifications Of Nanomofsmentioning

confidence: 99%

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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Exosome-Coated Metal–Organic Framework Nanoparticles: An Efficient Drug Delivery Platform

Cited by 191 publications

References 36 publications

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

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