Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress

Kamalden, Tengku Ain; Macgregor-Das, Anne M.; Sangeetha, Marimuthu Kannan; Dunkerly‐Eyring, Brittany; Khaliddin, Nurliza; Xu, Zhenhua; Fusco, anthony; Yazib, Syatirah Abu; Chow, Rhuen Chiou; Duh, Elia J.; Halushka, Marc K.; Steenbergen, Charles; Das, Samarjit

doi:10.1089/ars.2016.6844

Cited by 110 publications

(81 citation statements)

References 52 publications

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“…The upregulated levels of miR‐15a were linked to disease pathogenesis via the upregulation of oxidative stress. The results of these studies indicated that miRNA‐containing exosomes could have significant impact on the pathogenesis and progression of diabetic disease . To assess the value of exosome miRNAs as biomarkers in diabetes, one group examined the miRNA expression in plasma‐derived exosomes.…”

Section: Role Of Exosomesmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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Exosomes are a subset of extracellular vesicles released by all cell types and involved in local and systemic intercellular communication. In the past decade, research into exosomes has swelled as their important role in the mediation of health and disease has been increasingly established and acknowledged. Exosomes carry a diverse range of cargo including proteins, nucleic acids, and lipids derived from their parental cell that, when delivered to the recipient cell, can confer pathogenic or therapeutic effects through modulation of immunity and inflammation. In this review, the role of exosomes on mediation of immune and inflammatory responses, and their participation in diseases with a significant inflammatory component is discussed. The considerable potential for exosomes in therapy and diagnosis of inflammatory diseases is also highlighted.

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Section: Role Of Exosomesmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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“…MiR‐15a , a miRNA that plays an important role in insulin production in pancreatic β‐cells, is increased in the plasma of diabetic patients. Pancreatic miR‐15a can enter the bloodstream inside exosomes and may contribute to retinal injury and oxidative stress by targeting AKT3 in retinal cells . Another recent report showed that the exosome fraction isolated from mouse plasma was enriched in immunoglobulins (Igs) associated with the vesicles .…”

Section: Exosomes and Evs In Diabetesmentioning

confidence: 99%

Exosomes and diabetes

Castaño

Novials

Párrizas

2019

Diabetes Metabolism Res

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Summary Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life‐threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resistance in peripheral tissues such as liver, muscle, or the adipose depots. Communication between organs is thus central to the maintenance of glucose homoeostasis. Recently, several studies are evidencing that small vesicles called exosomes released by, amongst other, the adipose tissue can regulate gene expression in other tissues, hence modulating interorgan crosstalk. Therefore, exosomes participate in the development of diabetes and its associated complications. Their study holds the potential of providing us with novel biomarkers for the early diagnosis and stratification of patients at risk of developing diabetes, hence allowing the timely implementation of more personalized therapies. On the other hand, the molecular dissection of the pathways initiated by exosomes under situations of metabolic stress could help to gain a deeper knowledge of the pathophysiology of diabetes and its associated metabolic diseases.

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“…In addition, Yin et al have showed that miR-214 secreted by tumor cells can enter CD4+ T cells, repressing local expression of PTEN and thus affecting Treg proliferation [37]. Another group suggests that miR-15a, produced in pancreatic β-cells, can enter the bloodstream and contribute to retinal injury [38]. The way of such intercellular miRNA-mRNA regulation has been found in a wide range of biological processes [10].…”

Section: Functions Of Secreted Micrornasmentioning

confidence: 99%

Roles of extracellular microRNAs in central nervous system

Wang

2019

ExRNA

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MicroRNAs are small non-coding RNAs containing about 18-25 nucleotides which modulate gene expression post-transcriptionally. Recently, microRNAs have been detected in the extracellular space including a wide range of body fluids. These extracellular miRNAs, often encapsulated in secreted extracellular vesicles, can be transferred into recipient cells and thus inhibits the expression of targeted genes. In view of these findings, a new exosome-based therapeutic approach is invented, which can effectively deliver miRNAs/siRNAs into specific cells. In central nervous system, extracellular miRNAs can not only be used as noninvasive biomarkers for diagnosis of several neurological disorders, but also mediate the intercellular communication between neurons and glial cells. In this review, we will discuss the latest research work regarding the roles of secreted miRNAs in central nervous system and evaluate the potential of exosome-mediated miRNAs/siRNAs delivery in neural therapy.

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Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress

Cited by 110 publications

References 52 publications

Exosomes in Inflammation and Inflammatory Disease

Exosomes in Inflammation and Inflammatory Disease

Exosomes and diabetes

Roles of extracellular microRNAs in central nervous system

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