Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis

Chi, Yuan; He, Xin; Liu, Zhaoyu

doi:10.3389/fonc.2021.671082

Cited by 35 publications

(19 citation statements)

References 23 publications

(24 reference statements)

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“…MTT experiment was conducted based on the previous research [ 18 ]. Cells were seeded into the 96-well plate at 4 × 10 3 cells per well.…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway

Wang

et al. 2022

Bioengineered

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Most patients with ovarian cancer (OC) get remission after undergoing cytoreductive surgery and platinum-based standard chemotherapy, but more than 50% of patients with advanced OC relapse within the first 5 years after treatment and develop resistance to standard chemotherapy. The production of medicinal properties is the main reason for the poor prognosis and high mortality of OC patients. Cisplatin (DDP) resistance is a major cause for poor prognosis of OC patients. PTPRZ1 can regulate the growth and apoptosis of ovarian cancer cells, while the molecular mechanism remains unknown. This study was designed to investigate the roles of PTPRZ1 in DDP-resistant OC cells and possible mechanism. PTPRZ1 expression in OC tissues and normal tissues was analyzed by GEPIA database and verified by Real-time Quantitative Reverse Transcription PCR (RT-PCR) assay. PTPRZ1 expression in normal ovarian cancer cells and DDP-resistant OC cells was also analyzed. Subsequently, RT-PCR, Western blot, MTT experiment and flow cytometry were used to assess the effects of PTPRZ1-PI3K/AKT/mTOR regulating axis on DDP resistance of OC. PTPRZ1 expression was abnormally low in OC tissues, and notably reduced in DDP-resistant OC cells. MTT experiment and flow cytometer indicated that overexpression of PTPRZ1 enhanced the DDP sensitivity of OC cells and promoted the cell apoptosis. Moreover, the results of our research showed that PTPRZ1 might exert its biological effects through blocking PI3K/AKT/mTOR pathway. PTPRZ1 overexpression inhibitied OC tumor growth and resistance to DDP in vivo. Overall, PTPRZ1 might suppress the DDP resistance of OC and induce the cytotoxicity by blocking PI3K/AKT/mTOR pathway.

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“…MTT experiment was conducted based on the previous research [ 18 ]. Cells were seeded into the 96-well plate at 4 × 10 3 cells per well.…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway

Wang

et al. 2022

Bioengineered

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“…Exosomal transfer of lncRNA UCA1 promoted cell migration and tube formation of human umbilical vein endothelial cells (HUVECs), contributing to angiogenesis and tumor growth ( 89 ). Interestingly, lncRNA UCA1 was also enriched in exosomes derived from pancreatic stellate cells (PSCs), and such exosome was able to promote the Gemcitabine resistance of pancreatic cancer cells through SOCS3/EZH2 Axis ( 91 ). CircZNF91 was encapsulated and transmitted to normoxic pancreatic cancer cells through hypoxic exosomes, eventually enhancing the stability of HIF-1α and leading to glycolysis and chemoresistance of normoxic pancreatic cancer cells ( 87 ).…”

Section: Hypoxic Exosomes Promote the Development Of Different Types ...mentioning

confidence: 99%

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

et al. 2022

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Exosomes are small extracellular vesicles that are secreted by almost all types of cells and exist in almost all extracellular spaces. As an important mediator of intercellular communication, exosomes encapsulate the miRNA, lncRNA, cirRNA, mRNA, cytokine, enzyme, lipid, and other components from the cytoplasm into its closed single membrane structure and transfer them to recipient units in an autocrine, paracrine, or endocrine manner. Hypoxia is a state of low oxygen tension and is involved in many pathological processes. Hypoxia influences the size, quantity, and expression of exosome cargos. Exosomes derived from hypoxic tumor cells transfer genetics, proteins, and lipids to the recipient units to exert pleiotropic effects. Different donor cells produce different cargo contents, target different recipient units and lead to different biological effects. Hypoxic exosomes derived from tumor cells uptaken by normoxic tumor cells lead to promoted proliferation, migration, and invasion; uptaken by extracellular space or liver lead to promoted metastasis; uptaken by endothelial cells lead to promoted angiogenesis; uptaken by immune cells lead to promoted macrophage polarization and changed tumor immune microenvironment. In addition to various types of tumors, hypoxic exosomes also participate in the development of diseases in the cardiovascular system, neuron system, respiratory system, hematology system, endocrine system, urinary system, reproduction system, and skeletomuscular system. Understanding the special characteristics of hypoxic exosomes provide new insight into elaborating the pathogenesis of hypoxia related disease. This review summarizes hypoxia induced cargo changes and the biological effects of hypoxic exosomes in tumors and non-malignant diseases in different systems.

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“…Recently, the role of UCA1 in the chemoresistance of PaC has also been investigated. Chi et al showed that exosomal UCA1 derived from hypoxia-induced pancreatic stellate cells could promote gemcitabine resistance in PaC, via the SOCS3/EZH2 axis [81]. Besides, Liang et al also reported that UCA1 overexpression also could induce resistance to 5-Fu in PDAC cells [32].…”

Section: Uca1 Increases Drug Resistance In Pacmentioning

confidence: 99%

The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review

Sun¹,

Li²,

jiang³

et al. 2023

J. Cancer

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Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role in different biological processes and diseases, especially in the development of tumors. LncRNA UCA1, which is firstly identified in human bladder cancer, has been showed to be a tumor promoter in pancreatic cancer. Recent researches have showed that UCA1 might promote pancreatic carcinogenesis and progression, and correlate with drug resistance. In this review, we address the biological function and regulatory mechanism of UCA1 in pancreatic cancer, which might give a new approach for clinical diagnosis and treatment.

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Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis

Cited by 35 publications

References 23 publications

RETRACTED ARTICLE: Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway

RETRACTED ARTICLE: Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review

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