Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR‐520a‐3p/LIMK1 axis

Wang, Dongmei; Xing, Na; Yang, Tiehong; Liu, Junqi; Zhao, Hongxia; He, Jun; Ai, Yanqiu; Yang, Jianjun

doi:10.1002/cam4.3313

Cited by 51 publications

(40 citation statements)

References 31 publications

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“…Using Huh7 cells in vitro to simulate the insufficient radiofrequency ablation (RFA), the researcher found that exosomal lncRNA ASMTL-AS1 activated miR-342-3p/NLK/YAP signals, aggravating residual malignant hepatocellular carcinoma when RFA was insufficient, opening up a new way for the treatment of HCC and preventing its recurrence 42 . Wang et al measured the expression of lncRNA H19 in HCC by qRT-PCR and western blot, and found that it could up-regulate LIMK1 and inhibit apoptosis, promote the proliferation, migration, and metastasis of HCC treated with propanol 43 . In addition, exosomal lncRNAs are also meaningful for HCC diagnosis.…”

Section: Biological Components Of Exosomesmentioning

confidence: 99%

Exosome in Hepatocellular Carcinoma: an update

Chen¹,

Mao²,

Liu³

et al. 2021

J. Cancer

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Hepatocellular carcinoma (HCC) is a common malignant tumor in the digestive tract with limited therapeutic choices. Intercellular communication among cancer cells and their microenvironment is crucial to disease progression. Exosomes are extracellular vesicles secreted by multiple types of cells into the extracellular space, which contain a variety of active components of secretory cells, including lipids, proteins, RNA and DNA. This vesicle structure involves in the exchange of materials and information between cells and plays an important role in the development of many diseases. Studies have shown that exosomes participate in the communication between HCC cells and non-HCC cells and regulate the occurrence and development of hepatocellular carcinoma. Therefore, exosomes may be specific biomarkers for early diagnosis and metastasis of HCC, which are also potential targets for the treatment of HCC. This review summarizes the characteristic, types and biological functions of exosomes and discusses their research progress and application prospects in the diagnosis and treatment of HCC.

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Section: Biological Components Of Exosomesmentioning

confidence: 99%

Exosome in Hepatocellular Carcinoma: an update

Chen¹,

Mao²,

Liu³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

show abstract

“…lncRNAs are involved in the regulation of cell functioning due to their interaction with miRNAs to sponge them from their target mRNA; therefore, they can act as competitive endogenous RNAs (ceRNAs) (110). For example, lncRNA H19 promotes proliferation and migration but inhibits apoptosis of HCC cells via sponging miR-520a-3p, thereby, upregulating the LIMK1 gene that encodes the LIM domain kinase 1 protein (111). Additionally, exosomal lncRNA ASMTL-AS1 can promote HCC malignancy via sponging miR-342-3p and transactivating c-Myc to promote oncogenic MAPK family Nemo-like kinase (NLK) expression and yes-associated protein 1 (YAP) activation (112).…”

Section: Genomic and Transcriptomic Profiling Of Exosomal Non-coding mentioning

confidence: 99%

Genomic Landscape of Liquid Biopsy for Hepatocellular Carcinoma Personalized Medicine

Moldogazieva

Zavadskiy

Terentiev

2021

Cancer Genomics Proteomics

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Hepatocellular carcinoma (HCC) is the sixth most frequently diagnosed cancer and the third leading cause of cancer-related deaths worldwide. Advanced-stage HCC patients have poor survival rates and this requires the discovery of novel clear biomarkers for HCC early diagnosis and prognosis, identifying risk factors, distinguishing HCC from non-HCC liver diseases, and assessment of treatment response. Liquid biopsy has emerged as a novel minimally invasive approach to enable monitoring tumor progression, metastasis, and recurrence. Since the liquid biopsy analysis has relatively high specificity and low sensitivity in cancer early detection, there is a risk of bias. Next-generation sequencing (NGS) technologies provide accurate and comprehensive gene expression and mutational profiling of liquid biopsies including cell-free circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and genomic components of extracellular vesicles (EVs) including micro-RNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). Since HCC is a highly heterogeneous cancer, HCC patients can display various genomic, epigenomic, and transcriptomic patterns and exhibit varying sensitivity to treatment options. Identification 369 This article is freely accessible online.

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“…Co-incubation of the Propofol treated HCC cell-derived exosomes (Propofol-exo) with untreated HCC cells can mediate the inhibition of proliferation, metastasis and invasion of the latter, as well as inducing apoptosis. The exogenous transfection of lncRNA H19 overexpression vector to Propofol-exo can inhibit the expression of miR-520a-3p in HCC cells, so as to activate the expression of the downstream target oncogene LIM domain kinase 1 (LIMK1) and destroy the antagonistic effect of Propofol on the malignant biological behaviors of tumor cells ( 113 ).…”

Section: Exosomal Ncrnas In Hcc Progressionmentioning

confidence: 99%

Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma

et al. 2021

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Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.

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Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR‐520a‐3p/LIMK1 axis

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 51 publications

References 31 publications

Exosome in Hepatocellular Carcinoma: an update

Exosome in Hepatocellular Carcinoma: an update

Genomic Landscape of Liquid Biopsy for Hepatocellular Carcinoma Personalized Medicine

Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma

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