Exorphins derived from cow's milk casein elicit pseudo-allergic wheal-and-flare reactions in healthy children

Kurek, Michał; Ruëff, Franziska; Czerwionka-Szaflarska, Mieczysława; G, Doroszewska; Przybilla, Bernhard

doi:10.1016/s0335-7457(96)80082-7

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Opioid peptides alter not only the mechanism of neuromodulation in the central nervous system (CNS), but also trigger inflammation and food allergy [12,36]. It is known that subcutaneous injection of BCM7 causes local pseudo-allergic reactions, masts cell degranulation, and histamine secretion even in healthy children [37]. β-casomorphin-5 may cause mast cells degranulation in mice, confirming the nature of the allergenic potential of this peptide [38].…”

Section: Discussionmentioning

confidence: 99%

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders

et al. 2019

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Opioid peptides released during digestion of dietary proteins such as casein, were suggested to contribute to autism development, leading to the announcement of opioid excess hypothesis of autism. This paper examines role of enzyme proline dipeptidyl peptidase-4 (DPPIV; EC 3.4.14.5) and it is exogenous substrate, β-casomorphin-7 (BCM7) in autism etiology. Our study included measurements of DPPIV and BCM7 concentrations in serum and urine, which were analyzed with ELISA assays and activity of DPPIV was measured by colorimetric test. The effect of opioid peptides from hydrolysed bovine milk on DPPIV gene expression in peripheral blood mononuclear cells (PBMC) in autistic and healthy children was determined using the Real-Time PCR (Polymerase Chain Reaction) method. Our research included 51 healthy children and 86 children diagnosed with autism spectrum disorder (ASD, ICDF84). We determined that the concentration of BCM7 in serum was significantly, 1.6-fold, higher in the ASD group than in controls (p < 0.0001). Concentration of DPPIV was found to also be significantly higher in serum from ASD children compared to the control group (p < 0.01), while we did not notice significant difference in enzymatic activity of serum DPPIV between the two study groups. We confirmed correlation according to the gender between analyzed parameters. The inspiration for this study emanated from clinical experience of the daily diet role in relieving the symptoms of autism. Despite this, we have concluded that milk-derived opioid peptides and DPPIV are potentially factors in determining the pathogenesis of autism; conducted studies are still limited and require further research.

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Section: Discussionmentioning

confidence: 99%

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders

et al. 2019

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Section: Discussionmentioning

confidence: 95%

“…The observed wheal and flare reactions in the skin were similar to test reactions with histamine or codeine. Oral pretreatment with the H1 antagonist significantly inhibited the skin responses to b-casomorphin-7 that prove that histamine is the most important mediator of these reactions (27,28).The involvement of opioid receptors seems not to be clear and needs further study (29). The same authors have shown secretagogue effects on rodentsÕ mast cells after preincubation with synthetic b-casomorphin-7 as well as histamine release from peripheral blood leukocytes in vitro (23,30).…”

Section: Discussionmentioning

confidence: 99%

Content of β‐casomorphins in milk of women with a history of allergy

Sidor

Jarmołowska

Kaczmarski

et al. 2008

Pediatric Allergy Immunology

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The prevalence of food allergies increased over the past decade. Most symptoms of food allergy appear during the first 2 yr of life. The aim of this study was to determine the beta-casomorphin-5 and -7 (BCMs) in colostrum and milk of 12 breast-feeding women with a history and clinical manifestation of food allergy. The results were compared with the data obtained from a control group of healthy age-matched breast-feeding women. The level of BCM in women with food allergy was constant during lactation, whereas the highest level of opioid peptides was found in colostrums of healthy women with a subsequent rapid decrease in mature milk. These differences in BCMs profile between allergic and healthy breast-feeding women suggest that BCM content in the human milk may be an indicator of allergic conditions.

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“…Опиоидные пептиды изменяют не только механизм нейромодуляции в центральной нервной системе (ЦНС), но также вызывают воспаление и пищевую аллергию [25,26]. Известно, что подкожное введение β-КМ-7 вызывает местные псевдоаллергические реакции, дегрануляцию тучных клеток и секрецию гистамина даже у здоровых детей [27]. β-КМ -5 может вызывать дегрануляцию тучных клеток у мышей, что подтверждает природу аллергенного потенциала этого пептида [28].…”

Section: Comparative Characteristics Of the Biological Functions Of C...unclassified

The biological role of casomorphins (part 2): role in human pathology

Хавкин

Vasia²,

Novikova

2022

jour

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The second part of the review on casomorphins is devoted to the role of these biologically active peptides — products of phosphoprotein hydrolysis. Convincing data on the eff ect on the immune system, anti-oncogenic effect, on the motility and tone of smooth muscle fibers, the ability to control other aspects of the gastrointestinal tract activity—the transport function of the intestinal epithelium, water absorption, etc. The effect of β-casomorphins on the endocrine system, primarily on release of insulin and somatostatin. Particular attention should be paid to the question of the effect of β-casomorphins on the maternal organism during pregnancy and breastfeeding of the newborn. This is important because β-casomorphins can enter the central nervous system, being one of the factors in postpartum psychosis and depression. The study of the mechanisms of action of β-casomorphins will bring scientists closer to understanding the genesis and pathogenesis of a signifi cant spectrum of pathologies.

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Exorphins derived from cow's milk casein elicit pseudo-allergic wheal-and-flare reactions in healthy children

Cited by 6 publications

References 21 publications

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders

Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders

Content of β‐casomorphins in milk of women with a history of allergy

The biological role of casomorphins (part 2): role in human pathology

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