Content of β‐casomorphins in milk of women with a history of allergy

Sidor, Katarzyna; Jarmołowska, Beata; Kaczmarski, Maciej; Kostyra, Elżbieta; Iwan, Matgorzata; Kostyra, H.

doi:10.1111/j.1399-3038.2007.00711.x

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…The association between maternal atopy/allergy and HM composition is not consistent in the literature. Higher IL-4, IL-5, IL-13 ( 106 ), and beta-casomorphin-5 ( 107 ) in colostrum, and higher levels of IL-4 ( 108 ), lower levels of TGF-β1 ( 109 , 110 ), TGF-β2 ( 111 ), IL-10 ( 108 ) and proteome (including protease inhibitors and apolipoproteins) ( 112 ) in HM were found in women with history of allergic disease compared with non-allergic women. Higher levels of sCD14 were found in mothers with a positive vs. negative allergic history ( 113 ).…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

et al. 2020

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Human milk (HM) is dynamic and shows a high inter- and intra-individual variability. To characterize HM with precision, it is necessary to understand the factors that modulate its composition. The objective of this narrative review is to summarize the maternal, infant and methodological factors that affect HM composition. We searched SCOPUS and PubMed databases for articles related to factors that are known to or could potentially influence HM composition and volume across lactation periods. Our comprehensive review encompasses various maternal-, infant-related, and methodological factors that modulate aspects of HM composition including macro- and micronutrients, vitamins and minerals, as well as volume. The most profound changes were observed in HM lipids and lipophiles. Evidence exists for many of the infant-related factors known to affect the nutritive and non-nutritive components of HM (e.g., birth weight, gestational age, infant age/stage of lactation). In contrast, less is known with respect to maternal factors; where there is either limited research or conflicting evidence (e.g., maternal lifestyle, obstetric history, medical conditions), except for the mother's diet, for which there is a relatively well-established understanding. Equally, although many of the methodological factors (e.g., HM sampling, handling and analytics) are known to impact HM composition, few studies have investigated this as a primary outcome, making it an important area of future research in HM. Here we propose a systematic capture of numerous maternal- and infant-related characteristics to facilitate associative comparisons of HM data within and across studies. Additionally, it would be prudent to standardize the methodological aspects known to affect HM composition in analytics, not only for HM lipids and lipophiles, but also for those nutrients whose variability is yet less well-understood. Defining the factors determining HM composition with accuracy will open perspectives for maternal intervention to optimize milk composition for specific needs of infants.

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Section: Resultsmentioning

confidence: 99%

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

et al. 2020

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“…It is important to note here that females can also be influenced by β-casomorphin-5 and β-casomorphin-7 opioid peptides in lactation milk. While both β-casomorphin peptide concentrations changed with lactation phase in healthy breast-feeding females [ 31 ], concentrations remained the same throughout lactation in the breast milk of females with food allergies [ 33 ]. While this expected time-dependent β-casomorphin gradient in healthy lactating females inspires a comparative study of the interrelationships between breast-feeding period, respective genotypes, and breast cancer diagnosis, our current study group has inappropriate stratification to pursue this herein.…”

Section: Discussionmentioning

confidence: 99%

μ-Opioid receptor gene (OPRM1) polymorphism in patients with breast cancer

et al. 2015

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Structure-dependent μ-opioid receptor (MOR) activity is an important element in cancer opioid analgesic effectiveness. It is widely accepted that guanine (G) substitution for adenine (A) at OPRM1 gene sequence position 118 changes receptor glycosylation pattern. This is associated with decreased binding ability in both exogenous and endogenous opioids, resulting in increased human pain resistance. The endogenous opioid system’s function in body homeostasis maintenance is considered mainly regulatory, so its participation in breast tumor formation and progression is identified herein. We examine the association of the most frequent MOR (A118G) gene polymorphism on breast cancer risk in a Northeastern Polish population by PCR-RFLP comparison of A and G allele frequency at OPRM1 gene A118G polymorphic site in breast cancer-diagnosed patients with healthy control group frequencies. Our results highlight a strong association between G allele presence at μ-opioid receptor A118G and increased breast cancer incidence (OR = 3.3, 95 % CI 2.2–5.0, p < 0.0001) and female gender (OR = 2.0, 95 % CI 1.4–2.9, p = 0.0004). Consequently, OPRM1 G allele presence at that site is a highly significant risk factor in breast cancer development.

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“…TGF-β1 (30, 31, 35, 50, 68, 72, 75-77, 80, 81, 83, 122, 127, 131, 137, 148, 149, 152, 153) TGF-β2 (30,31,35,50,52,68,72,73,75,77,80,122,125,127,152) TGF-β3 (35) EGF (122) HGF (49,154) inhibitors CST3 (46,47) SERPIN-A1, A3, B1, C1, G1 (46,47) SPINT1 (46,47) Other Coenzyme A (157) β-casomorphin (158) sCD14 (8,31,72,75,77,83,131,148,153) Other factors did not differ. …”

Section: Growth Factorsmentioning

confidence: 99%

Factors affecting breast milk composition and potential consequences for development of the allergic phenotype

Munblit

Boyle

Warner

2015

Clin Experimental Allergy

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There is conflicting evidence on the protective role of breastfeeding in relation to allergic sensitization and disease. The factors in breast milk which influence these processes are still unclear and under investigation. We know that colostrum and breast milk contain a variety of molecules which can influence immune responses in the gut-associated lymphoid tissue of a neonate. This review summarizes the evidence that variations in colostrum and breast milk composition can influence allergic outcomes in the infant, and the evidence that maternal and environmental factors can modify milk composition. Taken together, the data presented support the possibility that maternal dietary interventions may be an effective way to promote infant health through modification of breast milk composition.

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Content of β‐casomorphins in milk of women with a history of allergy

Cited by 13 publications

References 28 publications

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors

μ-Opioid receptor gene (OPRM1) polymorphism in patients with breast cancer

Factors affecting breast milk composition and potential consequences for development of the allergic phenotype

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