Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cells

Guðmundsdóttir, Ása Bryndís; Ómarsdóttir, Sesselja; Brynjólfsdóttir, Ása; Paulsen, Berit S.; Ólafsdóttir, Elín Soffia; Freysdóttir, Jona

doi:10.1016/j.imlet.2014.11.008

Cited by 33 publications

(15 citation statements)

References 20 publications

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“…For example, swimming in the Icelandic blue lagoon has a good therapeutic effect on psoriasis. The EPS produced by the main strain of Cyanobacterium aponinum in this blue lake water can increase IL10 secretion from dendritic cells and reduce IL17 release from T cells, which may be responsible for the beneficial effects of the blue lake water in the treatment of psoriasis [10]. However, to our knowledge, studies on the treatment of psoriasis with EPS as a moisturizer and drug-loading material have not been reported to date.…”

Section: Introductionmentioning

confidence: 92%

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Song

Cheng

et al. 2019

IJMS

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An exopolysaccharides/calcipotriol (EPS/CPT) emulsion was prepared using bacterial EPS as emulsifier, sunflower oil as an oil phase and CPT as the loaded drug, and the effect of this emulsion on psoriasis vulgaris treatment was evaluated. An EPS composed of mannose (70.56%) and glucose (29.44%) was obtained from the marine mangrove bacteria Bacillus amyloliquefaciens ZWJ (Zhu Wenjing) strain. The EPS has significant emulsifying activity at the concentration of 1.5%. The prepared EPS/CPT emulsion has small and stable particle size, with a drug content of 0.00492%, and good spreading properties. The in vitro drug release results revealed that the emulsion showed a certain sustained release effect. In vitro and in vivo animal experiments show that the EPS/CPT emulsion can effectively treat psoriasis vulgaris by increasing the accumulation of CPT in psoriatic skin lesions and reducing the levels of inflammatory cells and inflammatory factors (TNF and IL6). Additionally, it has a certain effect on reducing the side effects associated with CPT. This study lays a foundation for the research of EPS in the topical application of medical materials and treatment of psoriasis.

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Section: Introductionmentioning

confidence: 92%

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Song

Cheng

et al. 2019

IJMS

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“…Mud maturation experiments carried out comparing the natural substrate with commercial ones (such as bentonite) showed in fact a strong impairment of the green biofilm growth in the second case [ 14 ]. Moreover, surveys on some of the Cyanobacterial species colonizing the Euganean muds also demonstrated their ability to produce bioactive molecules with anti-inflammatory and antioxidant properties [ 15 , 16 , 17 ], tested both in vitro [ 18 , 19 , 20 ] and in vivo [ 21 , 22 ]. The isolated Phormidium sp.…”

Section: Introductionmentioning

confidence: 99%

Microbiota of the Therapeutic Euganean Thermal Muds with a Focus on the Main Cyanobacteria Species

et al. 2020

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The Euganean Thermal District has been known since Roman times for the therapeutic properties of peloids, obtained from natural clays that have undergone a traditional maturation process. This leads to the growth of a green microbial biofilm with Cyanobacteria and the target species Phormidium sp. ETS-05 as fundamental components for their ability to synthetize anti-inflammatory molecules. Currently, in-depth studies on the microbiota colonizing Euganean peloids, as in general on peloids utilized worldwide, are missing. This is the first characterization of the microbial community of Euganean thermal muds, also investigating the effects of environmental factors on its composition. We analysed 53 muds from 29 sites (Spas) using a polyphasic approach, finding a stable microbiota peculiar to the area. Differences among mud samples mainly depended on two parameters: water temperature and shading of mud maturation plants. In the range 37–47 °C and in the case of irradiance attenuation due to the presence of protective roofs, a statistically significant higher mud Chl a content was detected. Moreover, in these conditions, a characteristic microbial and Cyanobacteria population composition dominated by Phormidium sp. ETS-05 was observed. We also obtained the complete genome sequence of this target species using a mixed sequencing approach based on Illumina and Nanopore sequencing.

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“…It has recently been suggested that the use of natural antioxidants, such as vitamins A and E, in skin care formulations could provide a preventive therapy for skin photoaging . Moreover, beauty‐improving formulations of skin care emulsion with seaweed extracts or micro algae added have also been reported .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effect of water and acetone extracts of Fucus vesiculosus on oxidative stability of skin care emulsions

Poyato

Thomsen

Hermund

et al. 2016

Euro J Lipid Sci & Tech

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A water and an acetone extract of the Icelandic brown algae Fucus vesiculosus were evaluated as potential natural sources of antioxidant compounds in skin care emulsions. To assess their efficacy in inhibiting lipid oxidation caused by photo-or thermoxidation, they were stored in darkness and room temperature as control conditions, and compared to samples stored under accelerated conditions (light and room temperature, or darkness and 40°C). The presence of extracts in the skin care emulsions induced remarkable colour changes when the emulsions were exposed to light, and more extensively under high temperature. High temperature also caused greater increments in the droplet size of the emulsions. The analysis of the tocopherol content, peroxide value and volatile compounds during the storage revealed that, whereas both water and acetone extracts showed (at 2 mg/g of emulsion) protective effect against thermooxidation, only the water extract showed antioxidant activity against photooxidation.Practical applications: This research is the basis of developing natural antioxidants derived from seaweed to limit lipid oxidation in skin care products.

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Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cells

Cited by 33 publications

References 20 publications

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Microbiota of the Therapeutic Euganean Thermal Muds with a Focus on the Main Cyanobacteria Species

Antioxidant effect of water and acetone extracts of Fucus vesiculosus on oxidative stability of skin care emulsions

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