Exopolysaccharide and biopolymer-derived films as tools for transdermal drug delivery

Laubach, Joseph; Joseph, Meerab; Brenza, Timothy M.; Gadhamshetty, Venkata; Sani, Rajesh K.

doi:10.1016/j.jconrel.2020.10.027

Cited by 27 publications

(19 citation statements)

References 104 publications

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“…Among the innovative drug delivery systems that HME can produce are the transdermal films. Transdermal films can avoid first-pass metabolism, do not cause pain during administration and can be easily applied by the patient, improving both the success of the treatment and the patient adhesion [ 128 , 129 ]. Due it being biocompatible and already in use in transdermal applications, ERS was used as the polymeric matrix in the development of transdermal films containing ibuprofen, to overcome its gastrointestinal irritation by oral intake.…”

Section: Hot Melt Extrusionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: Hot Melt Extrusionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…[ 38 ] Due to their natural origin, some are extracted from plants or animals, while some are obtained from bacterial fermentation processes. [ 108,109 ] Hence, it is difficult to perform batch‐to‐batch quality control and to characterize the properties of these natural polysaccharides. [ 38 ] Hyaluronic acid, for example, comes with a molecular weight ranging from 5 to 20 000 kDa in vivo.…”

Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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“…[10][11][12] Numerous delivery systems, including polysaccharide-based systems, have been investigated for transdermal applications and demonstrated notable success in the delivery of small molecules. 1,[13][14][15][16][17] However, transdermal delivery of high molecular-weight molecules, remains challenging. The molecules with molecular weight (MW) of higher than 500 Da are usually injected.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible nanocarriers for passive transdermal delivery of insulin based on self-adjusting N-alkylamidated carboxymethyl cellulose polysaccharides

Cohen

Tworowski

et al. 2022

Nanoscale Adv.

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Exopolysaccharide and biopolymer-derived films as tools for transdermal drug delivery

Cited by 27 publications

References 104 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Biocompatible nanocarriers for passive transdermal delivery of insulin based on self-adjusting N-alkylamidated carboxymethyl cellulose polysaccharides

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