Exokrine Pankreasfunktion unter dem Einfluß vorwiegendα-adrenerger Substanzen, indirekter Sympathomimetica und Dopamin

Heidbreder, E.; Sieber, Peter; Heidland, A.

doi:10.1007/bf01851069

Cited by 2 publications

(1 citation statement)

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“…Later work by Vaysse, Bastie, Pascal, Martinel, Fourtanier & Ribet (1977), using the isolated blood-perfused canine pancreas, and by Demol & Sarles (1980), using the conscious rat, supported this view. As inhibition of pancreatic E. E. ELISHA, D. HUTSON AND T. SCRATCHERD secretion and vasoconstriction occur at the same time, (Barlow, Greenwell, Harper & Scratcherd, 1965, 1971Vaysse et al 1977;Heidbreder, Sieber & Heidland, 1978) and as both appear to be mediated through the a-receptor, a pharmacological approach using receptor-blockade techniques does not differentiate between the two events (Dzieniszewski, Tiscornia, Palasciano & Sarles, 1974;Vaysse et al 1977;Demol & Sarles, 1980). This paper describes experiments which attempt to divorce vasomotor and secretary events and demonstrates that noradrenaline exerts its effects both directly on the secretary cell and indirectly by virtue of local vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

The direct inhibition of pancreatic electrolyte secretion by noradrenaline in the isolated perfused cat pancreas.

Elisha¹,

Hutson²,

Scratcherd³

1984

The Journal of Physiology

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SUMMARY1. The continuous infusion of noradrenaline into the arterial supply of the isolated saline-perfused pancreas caused a dose-dependent rise in perfusion pressure, a reduction in perfusion rate and an inhibition of pancreatic secretion.2. With increasing dose there was always a greater reduction in secretion rate than there was of perfusate flow rate.3. Manual reduction of the perfusion rate resulted in a reduction in secretion rate. 4. When noradrenaline reduced the perfusate flow by 44-2 + 6000 the secretion rate fell by 76-6 + 14-1 %. Manual reduction of the perfusion flow rate by a similar amount (43 0 + 5-7 %) only reduced the secretion rate by 41-4 + 7 0 00. 5. The infusion of noradrenaline, when all calcium had been removed from the perfusate, caused only a small increase in perfusion pressure with little change in the perfusion flow whilst at the same time the inhibition of electrolyte secretion was relatively unaffected.6. The vasomotor and secretary effects of noradrenaline were abolished by phentolamine.7. It is concluded that noradrenaline inhibits pancreatic electrolyte secretion by a direct action on the secretary cell and indirectly by vasoconstriction and that both these effects are mediated through the a-receptor.

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Section: Introductionmentioning

confidence: 99%