Exogenous Progesterone and Estradiol Benzoate on Early Embryonic Survival in the Pig

Be, Gentry; Anderson, L. L.; Rm, Melampy

doi:10.2527/jas1973.373722x

Cited by 11 publications

(7 citation statements)

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“…Generation of precursor metabolites and energy (8,6), cellular respiration ( Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (3,12), nuclear-transcribed mRNA catabolic process (3,11), mRNA catabolic process (3, 8.6) 1.17 n.r. of cellular protein metabolic process (6, 4.1), n.r.…”

Section: Gene Expression In Uterine Tissue Of Pregnant Sowsmentioning

confidence: 99%

“…The rate of fertilization is generally greater than 95%. Therefore, the loss of potential piglets is predominately the result of early embryonic (Days 10-30) death and fetal (Days 31-70) death [8]. Porcine embryos begin to attach to the endometrium on Days 13 and 14 of gestation, and attachment is completed on Days 18 to 24 of gestation [9].…”

Section: Introductionmentioning

confidence: 99%

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Differential Gene Expression in Uterine Endometrium During Implantation in Pigs1

Xiao

Chen

et al. 2015

Biology of Reproduction

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Embryonic mortality during the implantation period strongly affects litter size in pigs. To analyze the differentially expressed genes (DEGs) in the endometrium during implantation and further to identify candidate genes for litter size, tissues of endometrial attachment sites and intersites were collected from nine pregnant sows on Days 13, 18, and 24 of pregnancy. Endometrium tissue was also collected from another three nonpregnant sows. Samples were hybridized to the porcine Agilent GeneChip microarray. The analysis of gene expression patterns over the implantation period revealed 858 DEGs at endometrial attachment sites. Comparisons of the gene files of attachment sites and intersites revealed 12, 51, and 89 DEGs on Days 13, 18, and 24 of pregnancy, respectively. Annotated function was used to identify overrepresented genetic processes, and several biological processes were considered as the most enriched. Genes related to vascular development, proteolysis, RNA metabolism and translation, protein modification, immune response, and hormone-related are discussed in detail. Then we combined microarray technology and linkage analysis to select powerful candidate genes for quantitative trait loci affecting pig litter size. Eighty-seven DEGs were located in quantitative trait loci related to litter size, that is, total number born and number born alive. Those candidate genes were thought to affect litter size by influencing embryonic implantation. Furthermore, single nucleotide polymorphism of VEGFA was shown to be associated with litter size in pigs. This study identified candidate genes for litter size that were related to embryonic implantation and could be a resource for target studies of genetic markers for litter size in pigs.

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Section: Gene Expression In Uterine Tissue Of Pregnant Sowsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential Gene Expression in Uterine Endometrium During Implantation in Pigs1

Xiao

Chen

et al. 2015

Biology of Reproduction

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“…Implantation may occur in the presence of progesterone alone. This has been demonstrated by ovariectomy and hormone replacement therapy soon after mating in a variety of species including rabbit, guinea-pig and hamster (see Marcus & Shelesnyak, 1970) monkey (Meyer, Wolf & Arslan, 1969), sheep (Foote, Gooch, Pope & Cassida, 1957;Moor & Rowson, 1959;Bindon, 1971;Sarda, Robertson & Smeaton, 1973; Cumming, Baxter & Lawson, 1974), cow (Hawk, Brinsfield, Turner, Whitmore & Norcross, 1963) and pig (Gentry, Anderson & Melampy, 1973). This does not, however, exclude the involvement of oestrogens from the normal process since they may still exhibit a limited synergistic effect with progesterone.…”

Section: Ovarian Hormonesmentioning

confidence: 92%

Hormone involvement in the establishment of pregnancy

Sauer¹

1979

Reproduction

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“…Litter size is affected by the ovulation rate, fertilization rate, and conceptus survival in animals. The number of early embryos can potentially reach approximately 20, but litter size is reduced down to 10–13 piglets at the time of farrowing, and much of this reduction is attributed to spontaneous conceptus loss (Gentry, Anderson, & Melampy, ). The preimplantation period is one of the major periods of spontaneous embryonic loss.…”

Section: Introductionmentioning

confidence: 99%

mRNA/lncRNA expression patterns and the function of fibrinogen‐like protein 2 in Meishan pig endometrium during the preimplantation phases

Wang

Hua

Xue

et al. 2019

Molecular Reproduction Devel

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Embryonic implantation involves a complex and well‐coordinated interaction between the developing conceptus and maternal uterus, and the preimplantation period has a major impact on litter size in pigs. The present study aimed to investigate the vital messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that regulate preimplantation in Meishan pigs. The enriched Gene Ontology terms were all related to “binding.” Furthermore, “ECM‐receptor interaction” was predicted as an important pathway that regulated the success of implantation. We speculated that the differentially expressed mRNAs S100A9, ANXA8, MUC16, and FGL2 and the differentially expressed lncRNAs TCONS_11206566, TCONS_09904861, and TCONS_1252933 may play vital roles in the process of implantation. Furthermore, this study verified that FGL2 was highly expressed on Day 12 of pregnancy, and we also investigated the function of FGL2 during preimplantation in vivo. In conclusion, this study provides useful information for further analyses of the molecular mechanisms of implantation in Chinese domestic pigs.

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Exogenous Progesterone and Estradiol Benzoate on Early Embryonic Survival in the Pig

Cited by 11 publications

References 0 publications

Differential Gene Expression in Uterine Endometrium During Implantation in Pigs1

Differential Gene Expression in Uterine Endometrium During Implantation in Pigs1

Hormone involvement in the establishment of pregnancy

mRNA/lncRNA expression patterns and the function of fibrinogen‐like protein 2 in Meishan pig endometrium during the preimplantation phases

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