Exogenous mesenchymal stem cells affect the function of endogenous lung stem cells (club cells) in phosgene-induced lung injury

Ye, Kaili; He, Daikun; Shao, Yuchao; Xu, Ning; Jin, Chaoyuan; Zhang, Lin; Shen, Jie

doi:10.1016/j.bbrc.2019.04.182

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Mechanistically, this process is involved in pulmonary air-blood barrier repair and regulating inflammatory reactions (93). Further studies have confirmed the related mechanisms of action from various aspects, including regulation of the proliferation and differentiation of lung epithelial cells and endogenous lung stem cells (56) and repair via the proliferation of endogenous lung stem cells (94). Although most studies focusing on experimental models have demonstrated their validity, MSCs provide strong prospects for treating P-ALI (6,52,53,(94)(95)(96)(97)(98) (Table 2).…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 87%

“…Further studies have confirmed the related mechanisms of action from various aspects, including regulation of the proliferation and differentiation of lung epithelial cells and endogenous lung stem cells (56) and repair via the proliferation of endogenous lung stem cells (94). Although most studies focusing on experimental models have demonstrated their validity, MSCs provide strong prospects for treating P-ALI (6,52,53,(94)(95)(96)(97)(98) (Table 2). MSC-based therapy has been widely used in the clinical treatment stage of ARDS and has also achieved very good effects, and it is expected to be studied in the P-ALI clinic in the near future.…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 87%

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Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

2022

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Phosgene (COCl2) gas is a chemical intermediate of high-volume production with numerous industrial applications worldwide. Due to its high toxicity, accidental exposure to phosgene leads to various chemical injuries, primarily resulting in chemical-induced lung injury due to inhalation. Initially, the illness is mild and presents as coughing, chest tightness, and wheezing; however, within a few hours, symptoms progress to chronic respiratory depression, refractory pulmonary edema, dyspnea, and hypoxemia, which may contribute to acute respiratory distress syndrome or even death in severe cases. Despite rapid advances in medicine, effective treatments for phosgene-inhaled poisoning are lacking. Elucidating the pathophysiology and pathogenesis of acute inhalation toxicity caused by phosgene is necessary for the development of appropriate therapeutics. In this review, we discuss extant literature on relevant mechanisms and therapeutic strategies to highlight novel ideas for the treatment of phosgene-induced acute lung injury.

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Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 87%

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 87%

Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

2022

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“…According to Galli et al ( 2011 ), macrophages exhibit functional repolarization and shifting from the pro-inflammatory (M1) phenotype to an anti-inflammatory (M2) phenotype during tissue repair as M2 type secretes less cytokines and enhances tissue repair. In addition, Ye and colleagues proved that BMSCs can affect endogenous lung stem cells (club cells) via cytokines as well as vesicles and activate the Notch signaling thus enhancing the proliferation of club cells in phosgene induced lung injury (Ye et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia pretreatment enhances the therapeutic potential of mesenchymal stem cells (BMSCs) on ozone-induced lung injury in rats

Abdelrahman

Samy

et al. 2022

Cell Tissue Res

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Ozone (O3) gas is a double-sided weapon. It provides a shield that protects life on earth from the harmful ultraviolet (UV) rays, but ground-level O3 is considered an urban air pollutant. So, a rat model of chronic O3 inhalation was established to assess the biochemical and morphological alterations in the lung tissue and to investigate the ameliorative effects of bone marrow–derived mesenchymal stem cells (BMSCs) with or without hypoxia pre-treatment. Forty-two adult male albino rats were divided into four groups: control, ozone-exposed, normoxic BMSC-treated, and hypoxic BMSC-treated groups. Lung tissue sections were processed for light and electron microscope examination, immunohistochemical staining for caspase 3, and iNOS. Quantitative real-time PCR for IL-1α, IL-17, TNF-α, and Nrf2 mRNA gene expression were also performed. Chronic O3 exposure caused elevated inflammatory cytokines and decreased antioxidant Nrf2 mRNA expression. Marked morphological alterations with increased collagen deposition and elevated apoptotic markers and iNOS were evident. BMSC treatment showed immunomodulatory (decreased inflammatory cytokine gene expression), antioxidant (increased Nrf2 expression and decreased iNOS), and anti-apoptotic (decreased caspase3 expression) effects. Consequently, ameliorated lung morphology with diminished collagen deposition was observed. Hypoxia pretreatment enhanced BMSC survival by MTT assay. It also augmented the previously mentioned effects of BMSCs on the lung tissue as proved by statistical analysis. Lung morphology was similar to that of control group. In conclusion, hypoxia pretreatment represents a valuable intervention to enhance the effects of MSCs on chronic lung injury.

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“…1). Ye and colleagues proved BMSCs affect endogenous lung stem cells (club cells) via cytokines as well as vesicles and activate the Notch signaling thus affecting the proliferation of club cells in phosgeneinduced lung injury [68]. Another study shows BMSCs protect against LPS-induced lung injury by restituting alveolar bioenergetics through Cx43-dependent alveolar attachment and mitochondrial transfer [69].…”

Section: Discussionmentioning

confidence: 99%

Stem cell therapy: a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury

Han

Lian

et al. 2020

Stem Cell Res Ther

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Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity and mortality in ALI and acute respiratory distress syndrome (ARDS) patients. In particular, influenza virus, coronavirus, and other respiratory viruses circulate in nature in various animal species and can cause severe and rapidly spread human infections. Although scientific advancements have allowed for rapid progress to be made to understand the pathogenesis and develop therapeutics after each viral pandemic, few effective methods to treat virus-induced ALI have been described. Recently, stem cell therapy has been widely used in the treatment of various diseases, including ALI. In this review, we detail the present stem cell-based therapeutics for lung injury caused by influenza virus and the outlook for the future state of stem cell therapy to deal with emerging influenza and coronaviruses.

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Exogenous mesenchymal stem cells affect the function of endogenous lung stem cells (club cells) in phosgene-induced lung injury

Cited by 9 publications

References 22 publications

Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

Hypoxia pretreatment enhances the therapeutic potential of mesenchymal stem cells (BMSCs) on ozone-induced lung injury in rats

Stem cell therapy: a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury

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