Exogenous &lt;i&gt;Moraxella liquefaciens&lt;/i&gt; Endophthalmitis

Cooperman, Elliot W.; Friedman, Alan H.

doi:10.1159/000307506

Cited by 14 publications

(4 citation statements)

References 3 publications

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“…This is consistent with previous reports of endophthalmitis caused by other Moraxella organisms; all but two of the reported cases of endophthalmitis caused by Moraxella organisms have been delayed-onset and bleb-associated [1,2,3,8]; the remaining two reported cases were trauma-related [4]. Although all previously reported patients except for two presented with vision of hand motion or worse, all regained their baseline visual acuity except for two patients who developed retinal detachment after endophthalmitis treatment and one patient who lost vision because of extensive trauma [2].…”

Section: Commentsupporting

confidence: 93%

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Endophthalmitis caused by Moraxella osloensis

Berrocal

Miller

Flynn

2002

Graefe's Arch Clin Exp Ophthalmol

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Section: Commentsupporting

confidence: 93%

“…Moraxella species reported to have been isolated from endophthalmitis culture specimens include M. catarrhalis [1,2,8], M. nonliquefaciens [4,11], and M. liquefaciens [3]. We report Moraxella osloensis as a cause of endophthalmitis.…”

Section: Introductionmentioning

confidence: 88%

Endophthalmitis caused by Moraxella osloensis

Berrocal

Miller

Flynn

2002

Graefe's Arch Clin Exp Ophthalmol

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“…These organisms are very closely related, as determined by both DNA-DNA hybridization analysis (20) and transformation studies (2). M. bovis is the primary cause of bovine infectious keratoconjunctivitis (8), and M. lacunata is a pathogen which occasionally causes conjunctivitis in humans (3,16,19). A single strain of M. bovis is capable of producing one or the other of two pilin types, named Q (previously P) and I (previously x) for strain Epp63 (14,17).…”

mentioning

confidence: 99%

Interesting sequence differences between the pilin gene inversion regions of Moraxella lacunata ATCC 17956 and Moraxella bovis Epp63

Rozsa

Marrs

1991

J Bacteriol

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The bacterium Moraxella lacunata is a causative agent of human conjunctivitis and keratitis. We have previously reported construction of plasmid pMxLl, which includes a 5.9-kb fragment on which the pilin gene inversion region of M. lacunata resides. The inversion region of pMxLl was shown to invert when pMxLl was in an Escherichia coli host cell. In this report, we present Western immunoblot analysis using Moraxelia bovis Epp63 anti-I and anti-Q pilin sera which demonstrate that pMxLl makes pilin only when in orientation 1. The type 4 (MePhe) class of bacterial pili is found on a wide variety of gram-negative bacteria (4), including Moraxella bovis (14) and Moraxella lacunata (12). The type 4 piliated (P+) bacteria of the family Neisseriaceae (including Moraxella, Branhamella, Neisseria, and other genera) display several phenotypic differences from the equivalent nonpiliated (P-) bacteria. These phenotypes include colony morphology, pitting of agar, autoagglutination, pellicle formation, hemagglutination, twitching motility, and increased competence for natural DNA transformation (for a review, see reference 10).We have been studying the type 4 pilin gene regions of M. bovis and M. lacunata. These organisms are very closely related, as determined by both DNA-DNA hybridization analysis (20) and transformation studies (2). M. bovis is the primary cause of bovine infectious keratoconjunctivitis (8), and M. lacunata is a pathogen which occasionally causes conjunctivitis in humans (3,16,19). A single strain of M. bovis is capable of producing one or the other of two pilin types, named Q (previously P) and I (previously x) for strain Epp63 (14,17). The switch in expression between the tfpQ and tfpl pilin genes is due to an inversion of a 2.1-kb region of DNA (5, 13). When tfpQ is in the expression locus it is in orientation 1, while orientation 2 has tfpI in the expression locus. We have shown that a gene (piv) adjacent to the inversion region is required for inversions to occur (12). We have described both similarities and differences between the * Corresponding author.

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“…M. bovis and M. lacunata are very closely related, as determined by both DNA-DNA hybridization analysis (44) and transformation studies (4,5). M. bovis is an ocular pathogen of cattle, and M. lacunata is a pathogen that occasionally causes conjunctivitis in humans (1,2,8,31). A single strain of M. bovis is capable of producing one or the other of two pilin types, which are now called Q and I…”

mentioning

confidence: 99%

Identification, cloning, and sequencing of piv, a new gene involved in inverting the pilin genes of Moraxella lacunata

et al. 1990

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MoraxeUal lacunata is a bacterium that is a causative agent of human conjunctivitis and keratitis. We have previously cloned the Q and I p_n ( Both similarities and differences in the genetic organization of type 4 pilin genes occur in different bacterial species. One similarity is that P. aeruginosa, N. gonorrhoeae, and M. bovis pilin genes all appear to use rpoN (glnF, ntrA)-dependent promoters (18,19). RpoN has been shown to be the alternative sigma factor, cr4, required for transcriptional activation of some genes (reviewed in reference 22). Differences exist in the copy numbers of pilin genes among type 4 pili. P. aeruginosa strains only have a single copy of the pilin gene in each genome (29,35 (25,32). The switch in expression between Q and I pilin is due to an inversion of a 2.1-kilobase (kb) region of DNA (13,24).Among the best-characterized families of bacterial DNA inversion systems are the Hin system of Salmonella typhimurium, Gin and Cin of bacteriophages Mu and P1, and Pin of Escherichia coli (reviewed in reference 14); another is the newly described Min of plasmid pl5B (33

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Exogenous <i>Moraxella liquefaciens</i> Endophthalmitis

Cited by 14 publications

References 3 publications

Endophthalmitis caused by Moraxella osloensis

Endophthalmitis caused by Moraxella osloensis

Interesting sequence differences between the pilin gene inversion regions of Moraxella lacunata ATCC 17956 and Moraxella bovis Epp63

Identification, cloning, and sequencing of piv, a new gene involved in inverting the pilin genes of Moraxella lacunata

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