Exogenous Lipoid Pneumonia Due to Nasal Application of Petroleum Jelly

Brown, Andrew; Slocum, Philip; Putthoff, Stephen L.; Wallace, W.E.; Foresman, Brian H.

doi:10.1378/chest.105.3.968

Cited by 45 publications

(31 citation statements)

References 5 publications

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“…Although the most common sources of lipid within the alveoli, bronchioles and interstitial tissues are aspirated and/or inhaled exogenous mineral oils [2,3], our patient had no evident history of exposure to mineral oils or other fat-like materials. Besides his clinical history, the diffuse distribution of the lesions in this case appeared to differ from that seen in exogenous lipoid pneumonia, which is usually predominant in the lower and right middle lobes [5][6][7].…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Sato¹,

Takahashi²,

Amano³

et al. 1996

Eur Respir J

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D Di if ff fu us se e p pr ro og gr re es ss si iv ve e p pu ul lm mo on na ar ry y i in nt te er rs st ti it ti ia al l a an nd d i in nt tr ra a--a al lv ve eo ol la ar r c ch ho o--l le es st te er ro ol l g gr ra an nu ul lo om ma as s i in n c ch hi il ld dh ho oo od d ABSTRACT: We describe an 18 year old male with pulmonary interstitial and intra-alveolar cholesterol granulomas (PICG), which developed to severe respiratory failure over 15 yrs. The histological diagnosis was made on the basis of open lung biopsy findings at the age of 3 yrs and autopsy at 18 yrs of age. Although the pathological features of the lung were similar to that of paediatric patients with lipoid pneumonia coexisting with pulmonary alveolar proteinosis (PAP), gastro-oesophageal reflux (GOR) and a diverse group of severe primary diseases, the patient lacked evidence for any of these.We believe the present case provides a new example of a diffuse-type of lipoid pneumonia coexisting with pulmonary alveolar proteinosis, which we call cholesterol granulomas.

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Section: Discussionmentioning

confidence: 90%

“…Exogenous sources include mineral oil, administered as nose drops or laxatives, animal and vegetable oils [1][2][3]. Endogenous lipoid pneumonia (ELP) is usually associated with bronchial obstruction or, more rarely, certain chronic inflammatory diseases, such as bronchiectasis, lung abscess and tuberculosis [1].…”

mentioning

confidence: 99%

Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Sato¹,

Takahashi²,

Amano³

et al. 1996

Eur Respir J

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“…Aspiration of liquid paraffin (liquid petrolatum) used for the treatment of constipation or intranasal instillation of liquid paraffin as a component of nasal drop or petroleum jelly such as Vaseline or Mentholatum for relief of sinus congestion is the common cause of ELP (2)(3)(4). We herein report an adult patient diagnosed as ELP resulting from aspiration of liquid paraffin used as a lubricant.…”

Section: Introductionmentioning

confidence: 99%

Exogenous Lipoid Pneumonia Following Ingestion of Liquid Paraffin.

et al. 2002

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An asymptomatic patient with exogenous lipoid pneumonia (ELP) due to silent aspiration of liquid paraffin ingested as a lubricant was diagnosed by bronchoalveolar lavage (BAL). BAL fluid separated into oily upper phase and lower aqueous phase spontaneously. Microscopic analysis of BAL cells revealed the presence of lipid-laden alveolar macrophages. Classic histochemical staining and electron microscope examination indicated that neutral lipid was dominant but phospholipid was also present in the lipidladen macrophages. Together with the history of ingestion of liquid paraffin, we identified that the ingested liquid paraffin was the origin of the neutral lipid in the lipid-laden macrophages observed in the BAL fluid. (Internal Medicine 41: 483-486, 2002)

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“…Nach Opera tio nen sind Par af fin gra nu lo me be schrieben wor den, über de ren Auf tre ten uns aller dings bei in tak ter Schleim haut kei ne Infor ma tio nen vor lie gen [4]. Es gibt auch Fall be rich te über Li pid p neumo ni en nach lang jäh ri ger en do na sa ler Anwen dung von mi ne ral öl hal ti gen Na sen salben zur Nacht zeit [6]. Nach Hux ley et al [11] kommt nächt li che Aspi ra ti on re la tiv häu fig vor, so könn ten auch Na sen sal ben aspi riert wer den.…”

Section: Ta Bel Leunclassified

Die Anwendung lipidhaltiger Nasensalbe bei allergischer Rhinitis — eine Therapieoption?

Geisthoff

Rupp-Classen²,

Blum

et al. 2005

HNO

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The test agent used in our study contains a lipid fraction, in this case in the form of high purity, long chain hydrocarbons. By local application, a significant improvement of the total symptomatology was shown. The mechanism has not been clarified. Owing to the efficacy and low risk of side effects, this seems to be a promising adjuvant therapy for allergic rhinitis. The probetoric use of this nasal ointment as a supportive therapeutic option should be reviewed in further clinical studies.

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Exogenous Lipoid Pneumonia Due to Nasal Application of Petroleum Jelly

Cited by 45 publications

References 5 publications

Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Diffuse progressive pulmonary interstitial and intra-alveolar cholesterol granulomas in childhood

Exogenous Lipoid Pneumonia Following Ingestion of Liquid Paraffin.

Die Anwendung lipidhaltiger Nasensalbe bei allergischer Rhinitis — eine Therapieoption?

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