The patient cohort had a mean age of 52 years, with a range of 16 -79. Mean follow-up time was 11.9 months. The indications for image-guided trephination were: superiorly or laterally based mucoceles (4); fibrous dysplasia (2); type 4 frontal cell pathology (2); frontal recess stenosis with complicated frontal sinusitis (2). Four patients had previous external surgical approaches with secondary scarring in the frontoethmoid region. In 8 patients, image-guided trephination was combined with endoscopic transethmoid frontal sinusotomy, whereas 2 patients were successfully treated solely through a trephination approach. No patients required revision, and all patients remain symptom-free to date.Conclusions: Image-guided frontal trephination enables targeted localization of frontal sinus pathology for endoscopic surgical treatment. The image-guided frontal trephination procedure offers a minimally invasive, mucosal sparing technique that is an attractive alternative to osteoplastic flap.
The test agent used in our study contains a lipid fraction, in this case in the form of high purity, long chain hydrocarbons. By local application, a significant improvement of the total symptomatology was shown. The mechanism has not been clarified. Owing to the efficacy and low risk of side effects, this seems to be a promising adjuvant therapy for allergic rhinitis. The probetoric use of this nasal ointment as a supportive therapeutic option should be reviewed in further clinical studies.
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