Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway

Zhen, Yulan; Wu, Qiaomei; Ding, Yiqian; Zhang, Wei; Zhai, Yunkai; Lin, Xuemei; Weng, Yunxia; Guo, Ruixian; Zhang, Ying; Feng, Jianqiang; Lei, Yiyan; Chen, Jingfu

doi:10.3892/ol.2018.8154

Cited by 16 publications

(14 citation statements)

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“…In agreement with the above results, exogenous NaHS (500 µM) treatment facilitates the growth of hepatoma cells, and this effect may be relied on the nuclear factor-kappa B (NF-κB) pathway [148] . In addition, the same group has also shown that exogenous H 2 S (500 µM) facilitates the proliferation and migration of HCC cells by activating the STAT3/cyclooxygenase-2 (COX-2) signaling pathway [152] . However, treatment with NaHS (10 −3 M) inhibits the migration and proliferation of HCC cells through attenuating the PI3K/Akt/mTOR pathway and promoting the induction of autophagy [153] .…”

Section: Role Of H 2 S In Liver Cancermentioning

confidence: 99%

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Sun

Nie

et al. 2021

Journal of Advanced Research

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Section: Role Of H 2 S In Liver Cancermentioning

confidence: 99%

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Sun

Nie

et al. 2021

Journal of Advanced Research

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“…Mechanistically, H 2 S release from DATS was an allyl substituent reaction, during which a thiol will add to one of the alpha carbons or sulfur atoms of DATS (Benavides et al, ). Apart from naturally occurring H 2 S donors, sulfide salts (such as NaHS) and hydrolysis‐triggered donors (such as GYY4137) have been widely employed to evaluate the therapeutic potential of exogenous H 2 S against cancers as well (Lee et al, ; Zhen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Diallyl trisulfide, a H₂S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H₂S and cystathionine‐gamma‐lyase

Pan

Cheng

et al. 2020

Phytotherapy Research

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Diallyl trisulfide (DATS), derived from garlic, is a well‐known hydrogen sulfide (H2S) donor. H2S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H2S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC‐1 cells growth. DATS treatment triggered a rapid H2S generation within 5 min in KTC‐1 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H2S contributed to the apoptosis‐inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma‐lyase (CTH), one of H2S‐producing enzymes, which was responsible for endogenous H2S generation. After DATS treatment, H2S quickly permeated cell membranes and activated NF‐κΒ/p65 signaling pathway in KTC‐1 cells. Nuclear translocated NF‐κB bound to the promoter of CTH to enhance its transcription. These evidences proved that exogenous H2S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H2S. This positive feedback sustained excess H2S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H2S‐based antitumor agents.

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“…However, in contrast, and despite the anticancer efficacy in various types of cancer cells (e.g., gastric carcinoma, renal tumor), other studies have shown that H 2 S may induce tumor cell proliferation, and migration, as well as angiogenesis, via inhibiting apoptosis (122–124). Jia et al observed hepatoma cell suppression when CBS/H 2 S pathway was inhibited (125).…”

Section: Biological Properties Of Hydrogen Sulfidementioning

confidence: 97%

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

Viegas

Esteves

Cardoso

et al. 2019

Front. Public Health

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Natural mineral (thermal) waters have been used for centuries as treatment for various diseases. However, the scientific background of such therapeutic action is mostly empiric and based on knowledge acquired over time. Among the various types of natural mineral waters, sulfurous thermal waters (STWs) are the most common type in the center of Portugal. STWs are characterized by high pH, poor mineralization, and the presence of several ions and salts, such as bicarbonate, sodium, fluoride, silica, and carbonate. Furthermore, these waters are indicated as a good option for the treatment of various illnesses, namely respiratory diseases (e.g., allergic rhinitis, asthma, and chronic obstructive pulmonary disease). From the sulfide species present in these waters, hydrogen sulfide (H 2 S) stands out due to its abundance. In healthy conditions, H 2 S-related enzymes (e.g., cystathionine β-synthase and cystathionine γ-lyase) are expressed in human lungs, where they have mucolytic, antioxidant, anti-inflammatory, and antibacterial roles, thus contributing to airway epithelium homeostasis. These roles occur mainly through S-sulfhydration, a post-translational modification through which H 2 S is able to change the activity of several targets, such as ion channels, second messengers, proteins, among others. However, in respiratory diseases the metabolism of H 2 S is altered, which seems to contribute somehow to the respiratory deterioration. Moreover, H 2 S has been regarded as a good biomarker of airway dysfunction and severity, and can be measured in serum, sputum, and exhaled air. Hence, in this review we will recapitulate the effects of STWs on lung epithelial-immune crosstalk through the action of its main component, H 2 S.

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Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway

Abstract: Abstract. The effects of hydrogen sulfide (H 2 S) on cancer are controversial. Our group previously demonstrated that exogenous H 2 S promotes the development of cancer via amplifying the activation of the nuclear factor-κB signaling pathway in hepatocellular carcinoma (HCC) cells

Cited by 16 publications

References 50 publications

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Diallyl trisulfide, a H₂S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H₂S and cystathionine‐gamma‐lyase

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

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Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway

Abstract: Abstract. The effects of hydrogen sulfide (H 2 S) on cancer are controversial. Our group previously demonstrated that exogenous H 2 S promotes the development of cancer via amplifying the activation of the nuclear factor-κB signaling pathway in hepatocellular carcinoma (HCC) cells

Cited by 16 publications

References 50 publications

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

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Diallyl trisulfide, a H₂S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H₂S and cystathionine‐gamma‐lyase