Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Sun, Hai-Jian; Wu, Zhiyuan; Nie, Xiaowei; Wang, Xinyu; Bian, Jun

doi:10.1016/j.jare.2020.05.010

Cited by 59 publications

(43 citation statements)

References 150 publications

(195 reference statements)

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“…The liver is a fundamental site for endogenous H 2 S biosynthesis and detoxification. Hepatic H 2 S production has been previously implicated in the regulation of hepatic insulin sensitivity, and glucolipid metabolism [ 41 , 42 ]. Aberrant H 2 S production and signaling contribute to a plethora of chronic diseases of this organ, including non-alcoholic steatohepatitis, hepatocellular carcinoma, and liver fibrosis [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hepatic H 2 S production has been previously implicated in the regulation of hepatic insulin sensitivity, and glucolipid metabolism [ 41 , 42 ]. Aberrant H 2 S production and signaling contribute to a plethora of chronic diseases of this organ, including non-alcoholic steatohepatitis, hepatocellular carcinoma, and liver fibrosis [ 41 , 42 ]. Supplementation of H 2 S (with either NaHS or other classes of H 2 S donors) has been previously shown to suppress liver inflammation, ameliorate intracellular stress responses, and to counteract hepatic injury associated with a variety of insults ranging from ischemia-reperfusion, xenobiotic toxicity, and obesity, diabetes mellitus and metabolic disease (alone or in their various combinations) [ 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

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Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

2020

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It is estimated that over 1.5 billion people suffer from various forms of chronic liver disease worldwide. The emerging prevalence of metabolic syndromes and alcohol misuse, along with the lack of disease-modifying agents for the therapy of many severe liver conditions predicts that chronic liver disease will continue to be a major problem in the future. Better understanding of the underlying pathogenetic mechanisms and identification of potential therapeutic targets remains a priority. Herein, we explored the potential role of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide (H2S) system in the regulation of the endoplasmic reticulum (ER) stress and of its downstream processes in the immortalized hepatic cell line HepG2 in vitro. ER stress suppressed endogenous H2S levels and pharmacological supplementation of H2S with sodium hydrogen sulfide (NaHS) mitigated many aspects of ER stress, culminating in improved cellular bioenergetics and prevention of autophagic arrest, thereby switching cells’ fate towards survival. Genetic silencing of 3-MST or pharmacological inhibition of the key enzymes involved in hepatocyte H2S biosynthesis exacerbated many readouts related to ER-stress or its downstream functional responses. Our findings implicate the 3-MST/H2S system in the intracellular network that governs proteostasis and ER-stress adaptability in hepatocytes and reinforce the therapeutic potential of pharmacological H2S supplementation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

2020

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“…Since NO and H 2 S possess anti-oxidative properties [1][2][3][4][5][6][7][8][9][10][11]. Their decrease may favor oxidation and low-grade chronic inflammation.…”

Section: Overweight or Obesitymentioning

confidence: 99%

“…Hydrogen Sulphide (H 2 S) and Nitric Oxide (NO) are gasotransmitters with neuroprotective and anti-oxidative properties [1][2][3][4][5]. H 2 S increases autophagy and protects many organs such as liver [6,7], kidney [8], lungs [9], or heart and vessels [10]. It contributes to mucosal and immune defence against infection [11].…”

Section: Introductionmentioning

confidence: 99%

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Levels of Hydrogen Sulphide or Nitric Oxide in Induced Belching are Indicators of Adequate Gastric Voiding

Donatini¹,

Blaye²

2021

J Clin Case Stu

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Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H₂S and Reactive Oxygen Species

Ni,

Marutani,

Shieh

et al. 2024

Angewandte Chemie

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Hydrogen sulfide (H2S) is an endogenous gasotransmitter that plays important roles in redox signaling. H2S overproduction has been linked to a variety of disease states and therefore, H2S‐depleting agents, such as scavengers, are needed to understand the significance of H2S‐based therapy. It is known that elevated H2S can induce oxidative stress with elevated reactive oxygen species (ROS) formation, such as in H2S acute intoxication. We explored the possibility of developing catalytic scavengers to simultaneously remove H2S and ROS. Herein, we studied a series of selenium‐based molecules as catalytic H2S/H2O2 scavengers. Inspired by the high reactivity of selenoxide compounds towards H2S, 14 diselenide/monoselenide compounds were tested. Several promising candidates such as S6 were identified. Their activities in buffers, as well as in plasma‐ and cell lysate‐containing solutions were evaluated. We also studied the reaction mechanism of this scavenging process. Finally, the combination of the diselenide catalyst and photosensitizers was used to achieve light‐induced H2S removal. These Se‐based scavengers can be useful tools for understanding H2S/ROS regulations.

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Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Abstract: Graphical abstract

Cited by 59 publications

References 150 publications

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

Levels of Hydrogen Sulphide or Nitric Oxide in Induced Belching are Indicators of Adequate Gastric Voiding

Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H₂S and Reactive Oxygen Species

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Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Abstract: Graphical abstract

Cited by 59 publications

References 150 publications

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes

Levels of Hydrogen Sulphide or Nitric Oxide in Induced Belching are Indicators of Adequate Gastric Voiding

Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H2S and Reactive Oxygen Species

Contact Info

Product

Resources

About

Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H₂S and Reactive Oxygen Species