Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF-&lt;i&gt;β&lt;/i&gt;1 Signaling Pathway

Ye, Jin; Xiao, Cheng; Lu, Jinping; Li, Xia

doi:10.1620/tjem.244.1

Cited by 26 publications

(37 citation statements)

References 23 publications

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“…BMP-7 treatment significantly attenuated myocardial fibrosis, reduced the infarct size, and improved cardiac function. In addition, this study also reported that BMP-7 treatment inhibited myocardial fibrosis by attenuating TGF-β signaling and its downstream effectors Smad-2 and Smad-3 [211]. Furthermore, the beneficial role of BMP-7/Smad signaling has been shown in fibrotic disease of the heart [212,213].…”

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 53%

“…Moreover, exogenous administration of BMP-7 downregulates myocardial interstitial fibrosis as well as kidney fibrosis by inhibiting TGF-β signaling pathway and protects cardiac function. Recently, Jin et al demonstrated that exogenous BMP-7 facilitates cardiac function recovery after acute myocardial infarction by attenuating myocardial fibrosis through counteracting TGF-β1 signaling pathway [211]. In this study, the group established acute myocardial infarction by ligating the left anterior descending artery with and without BMP-7 treatment.…”

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 87%

“…The downregulation of BMP-7 in pathological fibrosis of organs has been reported [207][208][209][210][211][212]. Additionally, administration of exogenous BMP-7 or overexpression of BMP-7 protects the tissues such as kidneys [207,210], liver [208], lungs [209] and heart [211] from fibrosis. Moreover, exogenous administration of BMP-7 downregulates myocardial interstitial fibrosis as well as kidney fibrosis by inhibiting TGF-β signaling pathway and protects cardiac function.…”

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 94%

“…BMP-7 acts as an antifibrotic factor through the Smad pathway in which it induces the phosphorylation of Smad-1/5/8 and downregulates TGF-β signaling, which is mediated by Smad-2/3 phosphorylation [206]. The downregulation of BMP-7 in pathological fibrosis of organs has been reported [207][208][209][210][211][212]. Additionally, administration of exogenous BMP-7 or overexpression of BMP-7 protects the tissues such as kidneys [207,210], liver [208], lungs [209] and heart [211] from fibrosis.…”

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 99%

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The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

Narasimhulu

Singla

2020

Cells

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Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 stimulates the target cells by binding to specific membrane-bound receptor BMPR 2 and transduces signals through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. To date, rhBMP-7 has been used clinically to induce the differentiation of mesenchymal stem cells bordering the bone fracture site into chondrocytes, osteoclasts, the formation of new bone via calcium deposition and to stimulate the repair of bone fracture. However, its use in cardiovascular diseases, such as atherosclerosis, myocardial infarction, and diabetic cardiomyopathy is currently being explored. More importantly, these cardiovascular diseases are associated with inflammation and infiltrated monocytes where BMP-7 has been demonstrated to be a key player in the differentiation of pro-inflammatory monocytes, or M1 macrophages, into anti-inflammatory M2 macrophages, which reduces developed cardiac dysfunction. Therefore, this review focuses on the molecular mechanisms of BMP-7 treatment in cardiovascular disease and its role as an anti-fibrotic, anti-apoptotic and anti-inflammatory growth factor, which emphasizes its potential therapeutic significance in heart diseases.

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Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 53%

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 87%

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 94%

Section: Bmp-7 Inhibits Inflammation and Adverse Remodeling In The Inmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

Narasimhulu

Singla

2020

Cells

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“…Exogenouos administration of BMP7 improves left ventricular remodeling and function in acute myocardial infarction. 47 Trappin 2 is a serine protease inhibitor, and it has anti-inflammatory actions on the mucosal surfaces. 48 It also has anti-retrovirus activities on the mucosal surfaces.…”

Section: Streptococcus Pyogenes' Lysate Effects and Heat Map Analysismentioning

confidence: 99%

A Novel Method of Immunomodulation of Endothelial cells Using Streptococcus Pyogenes and its Lysate

Arokiaraj

Wilson

2020

Preprint

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Background:Coronary artery diseases and autoimmune disorders are common in clinical practice. In this study, a novel method of immune-modulation to modify the endothelial function was studied to modulate the features of the endothelial cells, and thereby to reduce coronary artery disease and other disorders modulated by endothelium. Methods:HUVEC cells were seeded in the cell culture, and streptococcus pyogenes were added to the cell culture, and the supernatant was studied for the secreted proteins. In the second phase, the bacterial lysate was synthesized, and the lysate was added to cell culture; and the proteins in the supernatant were studied at various time intervals. Results:When streptococcus pyogenes alone was added to culture, E Cadherin, Angiostatin, EpCAM and PDGF-AB were some of the biomarkers elevated significantly. HCC1, IGFBP2 and TIMP were some of the biomarkers which showed a reduction. When the lysate was added, the cell-culture was maintained for a longer time, and it showed the synthesis of immune regulatory cytokines. Heatmap analysis showed a significant number of proteins/cytokines concerning the immune/pathways, and toll-like receptors superfamily were modified. BLC, IL 17, BMP 7, PARC, Contactin2, IL 10 Rb, NAP 2 (CXCL 7), Eotaxin 2 were maximally increased. By principal component analysis, the results observed were significant. Conclusion:There is potential for a novel method of immunomodulation of the endothelial cells, which have pleiotropic functions, using streptococcus pyogenes and its lysates.

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Verifying the outcomes of artesunate plus 595‐nm PDL in hypertrophic scars via determining BMP‐7 and Fas level in model rabbits

et al. 2022

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Background and Objectives: Single-use of artesunate (ART) or 595-nm pulsed-dye laser (PDL) has proven clinical efficacy in the treatment of hypertrophic scars (HSs), yet little research has been done on the combined use of ART and PDL. Bone morphogenetic protein-7 (BMP-7) and Fas are recognized to be two important proteins in reducing scar formation. This study was designed to observe the effect of ART combined with 595-nm PDL in the treatment of HS in rabbit models, and investigate the effect of such protocol on the expression of BMP-7 and Fas in rabbit models. Study Design/Materials and Methods: Twenty-four New Zealand white rabbits were randomly divided into the control group, ART group, PDL group, and combined treatment (ART + PDL) group. ART was respectively applied to the ART group and combined treatment group. Treatment was once every 2-week for a total of three sessions for both groups. Animals in the PDL group were simply treated with 595-nm PDL. Then, hematoxylin & eosin and Van Gieson straining, immunohistochemical study, enzyme-linked immunosorbent assay (ELISA), Cell counting kit-8 test, western blot assay, and real-time polymerase chain reaction (RT-PCR) were carried out to observe the development of HS samples and expression of BMP-7 and Fas proteins in the sample tissues. Results: After treatment, the scar samples grew lower and flatter, which was particularly evident in the combined treatment group, with notably inhibited fibroblast and collagen compared to other groups (p < 0.001). Western blot assay and RT-PCR demonstrated that the expression of BMP-7 was most increased in scar samples treated by ART + PDL. BMP-7 level was correspondingly and notably upregulated in treatment groups, especially in the ART + PDL group. In addition, relevant expression of Fas was also higher after treatment, especially in the ART + PDL group compared to either ART or 595-nm PDL group. The difference was significant among groups (p < 0.001). Conclusions: Combined use of ART and 595-nm PDL can inhibit HSs in rabbit models via inhibiting extra fibroblast and collagens. The potential mechanism may be involved in enhanced BMP-7 and Fas expression. Our observations may create an alternative therapeutic strategy for HSs in the clinic.

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Exogenous BMP-7 Facilitates the Recovery of Cardiac Function after Acute Myocardial Infarction through Counteracting TGF-<i>β</i>1 Signaling Pathway

Cited by 26 publications

References 23 publications

The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

A Novel Method of Immunomodulation of Endothelial cells Using Streptococcus Pyogenes and its Lysate

Verifying the outcomes of artesunate plus 595‐nm PDL in hypertrophic scars via determining BMP‐7 and Fas level in model rabbits

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