The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

Abstract

Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 stimulates the target cells by binding to specific membrane-bound receptor BMPR 2 and transduces signals through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. To date, rhBMP-7 has been used clinically to induce the differentiation of mesenchymal stem cells bordering the bone fracture site into chondrocytes, osteoclasts, the formation of new bone via calcium deposition and to stimulate the repair of bone fracture. However, its use in cardiovascular diseases, such as atherosclerosis, myocardial infarction, and diabetic cardiomyopathy is currently being explored. More importantly, these cardiovascular diseases are associated with inflammation and infiltrated monocytes where BMP-7 has been demonstrated to be a key player in the differentiation of pro-inflammatory monocytes, or M1 macrophages, into anti-inflammatory M2 macrophages, which reduces developed cardiac dysfunction. Therefore, this review focuses on the molecular mechanisms of BMP-7 treatment in cardiovascular disease and its role as an anti-fibrotic, anti-apoptotic and anti-inflammatory growth factor, which emphasizes its potential therapeutic significance in heart diseases.

Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype

“… 10 , 27 , 48 This is highlighted by BMP7-driven attenuation of chondrocyte COX-2, IL-6, and PGE 2 levels in the present work, with similar actions for peptides p[63−82] and p[113−132]. BMP7 has previously also been reported as a morphogen with anti-inflammatory properties in other tissues and cell types like kidney, 49 heart, 50 blood vessels, 50 and macrophages. 51 The observation that these peptides attenuate PGE 2 release from intra-articular tissue other than cartilage (IPFP, meniscus, and not significantly from synovium) is in line with the previously reported tissue-wide anti-inflammatory actions of BMP7.…”

Development and Validation of a Random Forest Diagnostic Model of Acute Myocardial Infarction Based on Ferroptosis-Related Genes in Circulating Endothelial Cells

“…In addition, the KEGG pathway analysis of these differentially expressed genes showed that the top three signal pathways with the largest number of enriched genes were the TNF signaling pathway, osteoclast differentiation, and Toll-like receptor signaling pathway (Figure 2B). All these pathway enrichments were also supported and echoed by corresponding literature (13,27,28).…”

Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approach

“…Five viral miRNAs were predicted to act in synergy to regulate 2 genes (BMP7 and CD36) out of 4 significantly down-regulated genes related to immune and apoptotic functions. Previous studies reported that BMP-7 is associated with pathophysiology of several diseases[ 48 ]. Recent evidence suggested that antagonists of BMP signaling pathways may play critical role in the treatment of COVID-19 induced multi-organ failure[ 49 ].…”