Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids

Porta, Miquel; Ferrer-Armengou, Olga; Pumarega, José; López, Tomás; Crous‐Bou, Marta; Alguacil, Juan; Fitó, Montserrat; Jariod, Manuel; Vicente, Ángel Martín; Morales, Eva; Covas, Marı́a-Isabel; Puigdomènech, Elisa; Gupta, Nikhil

doi:10.1016/j.jclinepi.2007.08.013

Cited by 19 publications

(41 citation statements)

References 44 publications

(39 reference statements)

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“…Methods of the PANKRAS II study have been described in detail [10,18,[32][33][34][35][36][37][38][39][40]. Briefly, subject recruitment took place between 1992 and 1995 at five general hospitals in the Mediterranean part of Spain, where 185 incident cases of exocrine pancreatic cancer (EPC) were prospectively identified.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, subject recruitment took place between 1992 and 1995 at five general hospitals in the Mediterranean part of Spain, where 185 incident cases of exocrine pancreatic cancer (EPC) were prospectively identified. The present report is based on 144 EPC patients with blood measures of organochlorines and information on signs and symptoms (78% of the 185) [38]. Their mean age was 66.4 years (SD 12.5, median 67.7) and 85 (59%) were males.…”

Section: Methodsmentioning

confidence: 99%

“…All cases were independently reviewed by the study reference pathologists, unaware of the original diagnosis. A panel of clinical and surgical experts in gastrointestinal diseases reviewed hospital discharge diagnoses of all patients and achieved a consensual clinicopathological diagnosis [32,33,38].…”

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

“…Over 94% of the interviews took place in the 2 weeks before or after blood draw. Interviews included questions about occupation, lifestyle, and past clinical history [10,18,32,38,40]. Information on signs and symptoms of the disease was obtained from two sources: medical records (where they were registered by the attending physician at hospital admission and abstracted by a physician into the clinicopathological form) and patient interviews [17,18,40,41].…”

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

“…The cholestatic syndrome involved jaundice, hypocholia (clay-colored stools), and choluria (dark brown urine). The constitutional syndrome comprised fatigue, anorexia, and weight loss [38]. Patients were considered to have the complete syndrome when all three signs or symptoms were present, and partial syndrome when one or two were present.…”

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

See 4 more Smart Citations

Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Porta

Pumarega

López

et al. 2009

Cancer Causes Control

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

Section: Personal Interviews and Information On Symptomsmentioning

confidence: 99%

See 3 more Smart Citations

Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Porta

Pumarega

López

et al. 2009

Cancer Causes Control

Self Cite

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show abstract

Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study

et al. 2007

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There are no consensus guidelines or standards for epidemiologic and '-omics' studies using blood biomarkers on how to report the timing of extraction of blood samples. However, disease-induced changes in blood concentrations of exogenous and endogenous compounds may bias studies. The aim of the present report is to describe the timing of blood collection with respect to a variety of relevant clinical events in the PANKRAS II Study, and to suggest ways to display graphically the quantitative information. Subjects were 167 incident cases of exocrine pancreatic cancer prospectively recruited in five teaching hospitals in eastern Spain. Over 80% of patients had blood extracted during the first 6 months since onset of cancer symptoms, and 82% within the first month of admission to a study hospital. Over 80% of cases had blood drawn after an ultrasound, a CT scan or an ERCP, 25% after a laparotomy, and 37% after treatment onset. All three intervals from blood extraction to diagnosis, to treatment onset and to interview had a median of 0 days, and 88% of cases had blood drawn within 2 weeks of diagnosis. Over 72% of cases had concentrations of total lipids in the medium, normal range. Results suggest ways to report intervals involving blood biomarkers and may contribute to develop consensus guidelines and standards on the collection of blood samples in epidemiologic and '-omics' research.

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Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients

et al. 2011

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The diagnostic utility of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer (EPC) has not been properly studied, and few reports have analysed a clinically relevant spectrum of patients. The objective was to evaluate the clinical validity of detecting K-ras mutations in the diagnosis of EPC in a large sample of clinically relevant patients. We prospectively identified 374 patients in whom one of the following diagnoses was suspected at hospital admission: EPC, chronic pancreatitis, pancreatic cysts, and cancer of the extrahepatic biliary system. Mutations in the K-ras oncogene were analysed by PCR and artificial RFLP in 212 patients. The sensitivity and specificity of the K-ras mutational status for the diagnosis of EPC were 77.7% (95% CI: 69.2-84.8) and 78.0% (68.1-86.0), respectively. The diagnostic accuracy was hardly modified by sex and age. In patients with either mutated K-ras or CEA > 5 ng/ml, the sensitivity and specificity were 81.0% (72.9-87.6) and 62.6% (72.9-87.6), respectively. In patients with mutated K-ras and CEA > 5 ng/ml the sensitivity was markedly reduced. In comparisons with a variety of non-EPC patient groups sensitivity and specificity were both always greater than 75%. In this clinically relevant sample of patients the sensitivity and specificity of K-ras mutations were not sufficiently high for independent diagnostic use. However, it seems premature to rule out the utility of K-ras analysis in conjunction with other genetic and 'omics' technologies.

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Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids

Cited by 19 publications

References 44 publications

Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Influence of tumor stage, symptoms, and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer

Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study

Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients

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